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KS1/4-DAVLB, a monoclonal antibody-vinca alkaloid conjugate for site-directed therapy of epithelial malignancies.

作者信息

Bumol T F, Baker A L, Andrews E L, DeHerdt S V, Briggs S L, Spearman M E, Apelgren L D

机构信息

Lilly Research Laboratories, Indianapolis, Indiana.

出版信息

Targeted Diagn Ther. 1988;1:55-79.

PMID:2979063
Abstract
摘要

相似文献

1
KS1/4-DAVLB, a monoclonal antibody-vinca alkaloid conjugate for site-directed therapy of epithelial malignancies.
Targeted Diagn Ther. 1988;1:55-79.
2
Antitumor activity of the monoclonal antibody-Vinca alkaloid immunoconjugate LY203725 (KS1/4-4-desacetylvinblastine-3-carboxhydrazide) in a nude mouse model of human ovarian cancer.
Cancer Res. 1990 Jun 15;50(12):3540-4.
3
Disposition of the monoclonal antibody-vinca alkaloid conjugate KS1/4-DAVLB (LY256787) and free 4-desacetylvinblastine in tumor-bearing nude mice.
J Pharmacol Exp Ther. 1987 May;241(2):695-703.
4
In vivo selection of human tumor cells resistant to monoclonal antibody-Vinca alkaloid immunoconjugates.
Cancer Res. 1990 Dec 1;50(23):7634-40.
5
Disposition of the monoclonal antibody-vinca alkaloid conjugate, KS1/4-DAVLB (LY256787), in Fischer 344 rats and rhesus monkeys.单克隆抗体-长春花生物碱偶联物KS1/4-DAVLB（LY256787）在Fischer 344大鼠和恒河猴体内的处置情况。
Drug Metab Dispos. 1987 Sep-Oct;15(5):640-7.
6
Antitumor xenograft activity with a conjugate of a Vinca derivative and the squamous carcinoma-reactive monoclonal antibody PF1/D.
Cancer Res. 1987 Jun 15;47(12):3118-22.
7
The use of anthracycline-antibody complexes for specific antitumor activity.使用蒽环类抗生素 - 抗体复合物实现特异性抗肿瘤活性。
Targeted Diagn Ther. 1988;1:25-53.
8
Chemoimmunoconjugate development for ovarian carcinoma therapy: preclinical studies with vinca alkaloid-monoclonal antibody constructs.用于卵巢癌治疗的化学免疫缀合物研发：长春花生物碱-单克隆抗体构建体的临床前研究
Bioconjug Chem. 1993 Mar-Apr;4(2):121-6. doi: 10.1021/bc00020a003.
9
New antitumor monoclonal antibody-vinca conjugates LY203725 and related compounds: design, preparation, and representative in vivo activity.新型抗肿瘤单克隆抗体-长春花属植物缀合物LY203725及相关化合物：设计、制备及代表性体内活性
J Med Chem. 1989 Mar;32(3):548-55. doi: 10.1021/jm00123a007.
10
Monoclonal antibody-mediated targeting of alkylating agents for the treatment of cancer.单克隆抗体介导的烷化剂靶向治疗癌症。
Targeted Diagn Ther. 1988;1:123-56.

引用本文的文献

1
Epithelial glycoprotein-2 expression is subject to regulatory processes in epithelial-mesenchymal transitions during metastases: an investigation of human cancers transplanted into severe combined immunodeficient mice.
Histochem J. 1998 Oct;30(10):723-9. doi: 10.1023/a:1003486630314.
2
Solution stability of the monoclonal antibody-vinca alkaloid conjugate, KS1/4-DAVLB.
Pharm Res. 1991 Oct;8(10):1264-9. doi: 10.1023/a:1015899612117.