β-血小板球蛋白和平均血小板体积水平升高可能表明系统性红斑狼疮患者存在持续性血小板活化。
Elevated beta-thromboglobulin and mean platelet volume levels may show persistent platelet activation in systemic lupus erythematosus patients.
作者信息
Uyar Seyit, Abanonu Gül Babacan, Pehlevan Seval Masatlıoğlu, Karatoprak Cumali, Mengüç Meral Uluköylü, Daşkin Alper, Dolu Süleyman, Demirtunç Refik
机构信息
Department of Internal Medicine, University of Health Science, Antalya Training and Research Hospital, Turkey.
Department of Internal Medicine, University of Health Science, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.
出版信息
Adv Clin Exp Med. 2018 Sep;27(9):1279-1283. doi: 10.17219/acem/74389.
BACKGROUND
Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombotic events. Platelets become more active and they enlarge to release proteins from alpha granules for aggregation during the plaque formation period. Beta-thromboglobulin is one of the proteins released from alpha-granules when platelets are activated and used as a marker of platelet activation in vivo.
OBJECTIVES
The aim of this study was to evaluate the plasma levels of beta-thromoglobulin and mean platelet volume as markers of the presence of platelet activation in systemic lupus erythematosus patients compared with healthy controls.
MATERIAL AND METHODS
Thirty-seven SLE patients with a mean disease duration of 4.96 years and without any organ involvement as well as 30 healthy volunteers were included in the study. All patients were in remission of SLE.
RESULTS
The mean beta-thromboglobulin level was 97.36 ±55.8 ng/mL in the SLE group and 72.67 ±33.5 ng/mL in the control group (p = 0.029). The mean platelet volume level was 8.27 ±1.68 fL in the SLE group and 9.16 ±1.52 fL (p = 0.031) in the controls.
CONCLUSIONS
Elevated beta-thromboglobulin levels in systemic lupus erythematosus patients may be associated with platelet activation in the early stages of disease, whereas lower mean platelet volume levels in the same population may be due to the effects of hydroxychloroquine and the inactivity of SLE.
背景
系统性红斑狼疮（SLE）患者发生血栓事件的风险增加。在斑块形成期，血小板变得更加活跃并增大，以从α颗粒中释放蛋白质用于聚集。β-血小板球蛋白是血小板激活时从α颗粒中释放的蛋白质之一，在体内用作血小板激活的标志物。
目的
本研究的目的是评估与健康对照相比，系统性红斑狼疮患者血浆β-血小板球蛋白水平和平均血小板体积作为血小板激活存在的标志物。
材料与方法
本研究纳入了37例平均病程为4.96年且无任何器官受累的SLE患者以及30名健康志愿者。所有患者的SLE均处于缓解期。
结果
SLE组的平均β-血小板球蛋白水平为97.36±55.8 ng/mL，对照组为72.67±33.5 ng/mL（p = 0.029）。SLE组的平均血小板体积水平为8.27±1.68 fL，对照组为9.16±1.52 fL（p = 0.031）。
结论
系统性红斑狼疮患者β-血小板球蛋白水平升高可能与疾病早期的血小板激活有关，而同一人群中较低的平均血小板体积水平可能是由于羟氯喹的作用和SLE的不活动状态。
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