GSCALite：一个用于基因集癌症分析的网络服务器。
GSCALite: a web server for gene set cancer analysis.
机构信息
Department of Bioinformatics and Systems Biology, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
出版信息
Bioinformatics. 2018 Nov 1;34(21):3771-3772. doi: 10.1093/bioinformatics/bty411.
SUMMARY
The availability of cancer genomic data makes it possible to analyze genes related to cancer. Cancer is usually the result of a set of genes and the signal of a single gene could be covered by background noise. Here, we present a web server named Gene Set Cancer Analysis (GSCALite) to analyze a set of genes in cancers with the following functional modules. (i) Differential expression in tumor versus normal, and the survival analysis; (ii) Genomic variations and their survival analysis; (iii) Gene expression associated cancer pathway activity; (iv) miRNA regulatory network for genes; (v) Drug sensitivity for genes; (vi) Normal tissue expression and eQTL for genes. GSCALite is a user-friendly web server for dynamic analysis and visualization of gene set in cancer and drug sensitivity correlation, which will be of broad utilities to cancer researchers.
AVAILABILITY AND IMPLEMENTATION
GSCALite is available on http://bioinfo.life.hust.edu.cn/web/GSCALite/.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
摘要
癌症基因组数据的可用性使得分析与癌症相关的基因成为可能。癌症通常是一组基因的结果，单个基因的信号可能会被背景噪声掩盖。在这里，我们提出了一个名为基因集癌症分析（GSCALite）的网络服务器，用于分析癌症中一组基因的以下功能模块。（i）肿瘤与正常组织之间的差异表达，以及生存分析；（ii）基因组变异及其生存分析；（iii）与癌症途径活性相关的基因表达；（iv）基因的 miRNA 调控网络；（v）基因的药物敏感性；（vi）基因在正常组织中的表达和 eQTL。GSCALite 是一个用户友好的网络服务器，用于动态分析和可视化癌症中的基因集和药物敏感性相关性，这将对癌症研究人员具有广泛的用途。
可用性和实现
GSCALite 可在 http://bioinfo.life.hust.edu.cn/web/GSCALite/ 上使用。
补充信息
补充数据可在生物信息学在线获得。
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