Cucchi Davide, Menon Alessandra, Zanini Beatrice, Compagnoni Riccardo, Ferrua Paolo, Randelli Pietro
Department of Orthopaedics and Trauma Surgery, Universitätsklinikum Bonn, Bonn, Germany.
Laboratory of Applied Biomechanics, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.
J Knee Surg. 2019 Jun;32(6):483-489. doi: 10.1055/s-0038-1651530. Epub 2018 May 23.
Patient-specific instrumentation (PSI) may contribute to reduced blood loss related to total knee arthroplasty (TKA). The purpose of this study was to compare the estimated hemoglobin (Hb) and red blood cell volume (RBC) losses in two groups of patients undergoing TKA with PSI and conventional instrumentation. Pre- and postoperative blood samples were collected from 22 patients randomly assigned to receive a PSI-assisted or conventional TKA. Post- to preoperative Hb difference was calculated and RBC loss was estimated according to Sehat et al. A significant difference in Hb reduction in favor of the PSI group was registered on the last day of stay ( = 0.0084) and significant treatment effect ( = 0.027) on Hb reduction after intervention was found with a regression model for longitudinal measurements. This study demonstrated that PSI leads to a significant trend in earlier Hb regain. These promising results suggest a beneficial effect of PSI in blood loss reduction.
患者特异性器械（PSI）可能有助于减少全膝关节置换术（TKA）相关的失血。本研究的目的是比较两组接受PSI和传统器械TKA患者的估计血红蛋白（Hb）和红细胞体积（RBC）损失。从22例随机分配接受PSI辅助或传统TKA的患者中采集术前和术后血样。计算术后与术前Hb差异，并根据Sehat等人的方法估计RBC损失。在住院最后一天，记录到有利于PSI组的Hb降低有显著差异（P = 0.0084），并且通过纵向测量的回归模型发现干预后Hb降低有显著治疗效果（P = 0.027）。本研究表明，PSI导致Hb更早恢复的显著趋势。这些有前景的结果表明PSI在减少失血方面具有有益作用。
