Patel Payal B, Spudich Serena S
Division of Neuro-infectious Disease Clinical Research, Department of Neurology, Yale University, New Haven, Connecticut.
Division of Neurological Infections and Global Neurology, Department of Neurology, Yale University, New Haven, Connecticut.
Semin Neurol. 2018 Apr;38(2):238-246. doi: 10.1055/s-0038-1649334. Epub 2018 May 23.
With the advent of combination antiretroviral therapies, the mortality rate from HIV has declined, while the prevalence of long-term HIV-related neurologic complications continues to rise. Thirty-six million individuals are living with HIV around the world, many of whom reside in resource-limited settings. The majority of studies have focused on individuals residing in the developed world, while the impact of HIV disproportionately affects people living in developing countries. This review focuses on recent domestic and international studies regarding neurologic complications related to HIV, including opportunistic infections, peripheral neuropathy, cerebrovascular disease, and HIV-associated neurocognitive disorders, in light of the growing population affected by these conditions.
随着联合抗逆转录病毒疗法的出现,HIV导致的死亡率有所下降,而与HIV相关的长期神经并发症的患病率却持续上升。全球有3600万人感染了HIV,其中许多人生活在资源有限的地区。大多数研究都集中在发达国家的人群,而HIV的影响对发展中国家人民的影响尤为严重。鉴于受这些疾病影响的人群不断增加,本综述重点关注了近期国内外关于与HIV相关的神经并发症的研究,包括机会性感染、周围神经病变、脑血管疾病以及HIV相关神经认知障碍。