Soucek Filip, Starek Zdenek
International Clinical Research Center, St. Anne`s University Hospital Brno, Brno, Czech Republic and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Curr Cardiol Rev. 2018;14(3):185-191. doi: 10.2174/1573403X14666180524100608.
Arrhythmia management is a complex process involving both pharmacological and non-pharmacological approaches. Radiofrequency ablation is the pillar of nonpharmacological arrhythmia treatment. Unipolar ablation is considered to be the gold standard in the treatment of the majority of arrhythmias; however, its efficacy is limited to specific cases. In particular, the creation of deep or transmural lesions to eliminate intramurally originating arrhythmias remains inadequate. Bipolar ablation is proposed as an alternative to overcome unipolar ablation boundaries.
Despite promising results gained from in vitro and animal studies showing that bipolar ablation is superior in creating transmural lesions, the use of bipolar ablation in daily clinical practice is limited. Several studies have been published showing that bipolar ablation is effective in the treatment of clinical arrhythmias after failed unipolar ablation, however, there is inconsistency regarding the safety of bipolar ablation within the available research papers. According to research evidence, the most common indications for bipolar ablation use are ventricular originating rhythmic disorders in patients with structural heart disease resistant to standard radiofrequency ablation.
To allow wider clinical application the efficiency and safety of bipolar ablation need to be verified in future studies.
心律失常的管理是一个复杂的过程,涉及药物和非药物方法。射频消融是非药物性心律失常治疗的支柱。单极消融被认为是大多数心律失常治疗的金标准;然而,其疗效仅限于特定病例。特别是,为消除壁内起源的心律失常而创建深部或透壁性病变仍然不足。双极消融被提议作为克服单极消融局限性的一种替代方法。
尽管体外和动物研究取得了有前景的结果,表明双极消融在创建透壁性病变方面更具优势,但双极消融在日常临床实践中的应用仍然有限。已有多项研究发表,表明双极消融在单极消融失败后的临床心律失常治疗中有效,然而,现有研究论文中关于双极消融安全性的观点并不一致。根据研究证据,双极消融最常见的应用指征是对标准射频消融耐药的结构性心脏病患者的室性起源节律紊乱。
为了实现更广泛的临床应用,双极消融的有效性和安全性需要在未来的研究中得到验证。