KU Leuven, Department of Immunology and Microbiology, Laboratory of Nephrology, Leuven, Belgium.
Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Kidney Int. 2018 Jun;93(6):1275-1277. doi: 10.1016/j.kint.2018.01.038.
A post hoc analysis of data from the EVOLVE study demonstrates that cinacalcet-induced hypocalcemia is common, mostly asymptomatic, and resolves spontaneously. These findings are reassuring and may warrant therapeutic inertia. However, previous studies in parathyroidectomized patients suggest that calcium repletion may be beneficial and safe from bone and cardiovascular perspectives, respectively, and as such call into question the appropriateness of a "sit back and relax" attitude toward cinacalcet-induced hypocalcemia.
EVOLVE 研究数据的事后分析表明，西那卡塞引起的低钙血症很常见，大多无症状，且会自发缓解。这些发现令人安心，可能需要治疗惰性。然而，甲状旁腺切除术患者的先前研究表明，从骨骼和心血管角度来看，补钙可能是有益且安全的，因此，对西那卡塞引起的低钙血症采取“坐视不管”的态度是否合适值得怀疑。
