低剂量奥美拉唑对十二指肠溃疡患者胃酸分泌的影响。

Effect of low-dose omeprazole on gastric acid secretion in duodenal ulcer patients.

作者信息

McLauchlan G, Crean G P, McColl K E

机构信息

Gastrointestinal Centre, Southern General Hospital, Glasgow, UK.

出版信息

Aliment Pharmacol Ther. 1988 Jun;2(3):263-8. doi: 10.1111/j.1365-2036.1988.tb00696.x.

DOI:10.1111/j.1365-2036.1988.tb00696.x

PMID:2979250

Abstract

The effect of 7 days of oral dosing with 5 mg day-1 and 20 mg day-1 omeprazole on basal and pentagastrin-stimulated gastric acid output was studied in nine duodenal ulcer patients. Basal acid output measured 5-6 h post-dosing was decreased by a mean of 75% on 5 mg omeprazole and by 90% on 20 mg omeprazole (P less than 0.05 and P less than 0.01, respectively). Peak acid output measured 6-7 h post-dosing was decreased by a mean of 75% on 5 mg omeprazole and 97% on 20 mg omeprazole (P less than 0.01 for each). There was a wide interindividual variation in response to the 5 mg dose, with five of the nine patients having more than 90% inhibition of peak acid output, but two patients having less than 40% inhibition. This unpredictable response to daily low-dose omeprazole therapy makes it unsuitable for maintenance treatment.

摘要

在9名十二指肠溃疡患者中研究了连续7天口服5毫克/天和20毫克/天奥美拉唑对基础胃酸分泌量和五肽胃泌素刺激的胃酸分泌量的影响。给药后5 - 6小时测得的基础胃酸分泌量，服用5毫克奥美拉唑时平均降低75%，服用20毫克奥美拉唑时平均降低90%（分别为P < 0.05和P < 0.01）。给药后6 - 7小时测得的胃酸分泌峰值，服用5毫克奥美拉唑时平均降低75%，服用20毫克奥美拉唑时平均降低97%（两者均为P < 0.01）。对5毫克剂量的反应存在广泛的个体差异，9名患者中有5名患者的胃酸分泌峰值抑制率超过90%，但有2名患者的抑制率低于40%。这种对每日低剂量奥美拉唑治疗不可预测的反应使其不适用于维持治疗。