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高分辨率 CT 对慢性肺移植功能障碍阻塞型和限制型表型的发现:不仅仅是闭塞性细支气管炎综合征。

High-Resolution CT Findings of Obstructive and Restrictive Phenotypes of Chronic Lung Allograft Dysfunction: More Than Just Bronchiolitis Obliterans Syndrome.

机构信息

1 Department of Radiology, Division of Cardiothoracic Imaging, Temple University Hospital, 3401 N Broad St, Philadelphia, PA 19140.

出版信息

AJR Am J Roentgenol. 2018 Jul;211(1):W13-W21. doi: 10.2214/AJR.17.19041. Epub 2018 May 24.

Abstract

OBJECTIVE

The purpose of this article is to review the high-resolution CT characteristics of individual obstructive and restrictive chronic lung allograft dysfunction (CLAD) phenotypes to aid in making accurate diagnoses and guiding treatment.

CONCLUSION

Long-term survival and function after lung transplant are considerably worse compared with after other organ transplants. CLAD is implicated as a major limiting factor for long-term graft viability. Historically thought to be a single entity, bronchiolitis obliterans syndrome, CLAD is actually a heterogeneous group of disorders with distinct subtypes.

摘要

目的

本文旨在回顾个体阻塞性和限制性慢性肺移植功能障碍(CLAD)表型的高分辨率 CT 特征,以帮助做出准确诊断和指导治疗。

结论

与其他器官移植相比,肺移植后的长期存活率和功能明显较差。CLAD 被认为是长期移植物存活的主要限制因素。既往认为是单一实体的闭塞性细支气管炎综合征,实际上 CLAD 是一组具有不同亚型的异质性疾病。

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