van Son Dana, Schalbroeck Rik, Angelidis Angelos, van der Wee Nic J A, van der Does Willem, Putman Peter
Institute of Psychology, Leiden University, Leiden, The Netherlands; Leiden Institute for Brain and Cognition, Leiden, The Netherlands.
Institute of Psychology, Leiden University, Leiden, The Netherlands.
Biol Psychol. 2018 Jul;136:100-110. doi: 10.1016/j.biopsycho.2018.05.006. Epub 2018 May 21.
Spontaneous EEG theta/beta ratio (TBR) probably marks prefrontal cortical (PFC) executive control, and its regulation of attentional threat-bias. Caffeine at moderate doses may strengthen executive control through increased PFC catecholamine action, dependent on basal PFC function.
To test if caffeine affects threat-bias, moderated by baseline frontal TBR and trait-anxiety.
A pictorial emotional Stroop task was used to assess threat-bias in forty female participants in a cross-over, double-blind study after placebo and 200 mg caffeine.
At baseline and after placebo, comparable relations were observed for negative pictures: high TBR was related to low threat-bias in low trait-anxious people. Caffeine had opposite effects on threat-bias in low trait-anxious people with low and high TBR.
This further supports TBR as a marker of executive control and highlights the importance of taking baseline executive function into consideration when studying effects of caffeine on executive functions.
自发脑电图θ/β比值（TBR）可能标志着前额叶皮质（PFC）的执行控制及其对注意力威胁偏向的调节。中等剂量的咖啡因可能通过增强PFC儿茶酚胺作用来加强执行控制，这取决于基础PFC功能。
测试咖啡因是否会影响威胁偏向，该影响是否受基线额叶TBR和特质焦虑的调节。
在一项交叉、双盲研究中，对40名女性参与者在服用安慰剂和200毫克咖啡因后，使用图片情绪Stroop任务来评估威胁偏向。
在基线和服用安慰剂后，对于负面图片观察到类似的关系：在低特质焦虑的人群中，高TBR与低威胁偏向相关。咖啡因对低特质焦虑且TBR低和高的人群的威胁偏向有相反的影响。
这进一步支持TBR作为执行控制的标志物，并强调在研究咖啡因对执行功能的影响时考虑基线执行功能的重要性。
