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Reducing mortality in newly diagnosed standard-risk acute promyelocytic leukemia in elderly patients treated with arsenic trioxide requires major reduction of chemotherapy: a report by the French Belgian Swiss APL group (APL 2006 trial).在接受三氧化二砷治疗的老年新诊断标准风险急性早幼粒细胞白血病患者中降低死亡率需要大幅减少化疗：法国-比利时-瑞士急性早幼粒细胞白血病研究组报告（APL 2006试验）
Haematologica. 2018 Nov;103(11):e519-e521. doi: 10.3324/haematol.2018.193151. Epub 2018 May 24.
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Comparison of induction therapy in non-high risk acute promyelocytic leukemia with arsenic trioxide or in combination with ATRA.三氧化二砷单药或联合全反式维甲酸用于非高危急性早幼粒细胞白血病诱导治疗的比较
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Long-term outcome of relapsed acute promyelocytic leukemia treated with oral arsenic trioxide-based reinduction and maintenance regimens: A 15-year prospective study.口服三氧化二砷为基础的再诱导和维持方案治疗复发急性早幼粒细胞白血病的长期疗效：一项 15 年的前瞻性研究。
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本文引用的文献

1
Long-term outcome of older patients with newly diagnosed de novo acute promyelocytic leukemia treated with ATRA plus anthracycline-based therapy.初诊的老年新发急性早幼粒细胞白血病患者接受 ATRA 联合蒽环类药物治疗的长期预后。
Leukemia. 2018 Jan;32(1):21-29. doi: 10.1038/leu.2017.178. Epub 2017 Jun 6.
2
Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial.维甲酸和三氧化二砷与维甲酸和化疗治疗非高危急性早幼粒细胞白血病的疗效比较：意大利-德国 APL0406 随机试验的最终结果。
J Clin Oncol. 2017 Feb 20;35(6):605-612. doi: 10.1200/JCO.2016.67.1982. Epub 2016 Oct 31.
3
Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial.三氧化二砷和全反式维甲酸治疗所有风险组急性早幼粒细胞白血病（AML17）：一项随机、对照、3 期临床试验的结果。
Lancet Oncol. 2015 Oct;16(13):1295-305. doi: 10.1016/S1470-2045(15)00193-X. Epub 2015 Sep 14.
4
Early death in acute promyelocytic leukemia (APL) in French centers: a multicenter study in 399 patients.法国各中心急性早幼粒细胞白血病（APL）患者的早期死亡情况：一项针对399例患者的多中心研究。
Leukemia. 2014 Dec;28(12):2422-4. doi: 10.1038/leu.2014.240. Epub 2014 Aug 21.
5
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia.全反式维甲酸和三氧化二砷联合治疗急性早幼粒细胞白血病。
N Engl J Med. 2013 Jul 11;369(2):111-21. doi: 10.1056/NEJMoa1300874.
6
Long-term follow-up of European APL 2000 trial, evaluating the role of cytarabine combined with ATRA and Daunorubicin in the treatment of nonelderly APL patients.欧洲 APL 2000 试验的长期随访结果，评估阿糖胞苷联合 ATRA 和柔红霉素在治疗非老年 APL 患者中的作用。
Am J Hematol. 2013 Jul;88(7):556-9. doi: 10.1002/ajh.23451. Epub 2013 Jun 12.
7
Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry.急性早幼粒细胞白血病的持续高早期死亡率：来自瑞典成人急性白血病登记处的一项基于人群的报告。
Leukemia. 2011 Jul;25(7):1128-34. doi: 10.1038/leu.2011.78. Epub 2011 Apr 19.
8
Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome.基于全反式维甲酸和蒽环类药物联合阿糖胞苷巩固治疗高危患者的急性早幼粒细胞白血病的风险适应性治疗：治疗结果的进一步改善。
Blood. 2010 Jun 24;115(25):5137-46. doi: 10.1182/blood-2010-01-266007. Epub 2010 Apr 14.
9
Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet.急性早幼粒细胞白血病的管理：代表欧洲白血病网的专家小组建议
Blood. 2009 Feb 26;113(9):1875-91. doi: 10.1182/blood-2008-04-150250. Epub 2008 Sep 23.
10
Is cytarabine useful in the treatment of acute promyelocytic leukemia? Results of a randomized trial from the European Acute Promyelocytic Leukemia Group.阿糖胞苷对急性早幼粒细胞白血病的治疗是否有效？来自欧洲急性早幼粒细胞白血病研究组的一项随机试验结果
J Clin Oncol. 2006 Dec 20;24(36):5703-10. doi: 10.1200/JCO.2006.08.1596. Epub 2006 Nov 20.

Reducing mortality in newly diagnosed standard-risk acute promyelocytic leukemia in elderly patients treated with arsenic trioxide requires major reduction of chemotherapy: a report by the French Belgian Swiss APL group (APL 2006 trial).

作者信息

Rahmé Ramy, Ades Lionel, Thomas Xavier, Guerci-Bresler Agnès, Pigneux Arnaud, Vey Norbert, Raffoux Emmanuel, Castaigne Sylvie, Spertini Olivier, Wittnebel Sebastian, Marolleau Jean Pierre, Damaj Gandhi, Bordessoule Dominique, Lejeune Julie, Chevret Sylvie, Fenaux Pierre

机构信息

Hôpital Saint Louis, Université Paris Diderot, France.

Hospices Civils de Lyon, Département d'Hématologie, Centre Hospitalier Lyon-Sud, Pierre Bénite, France.

出版信息

Haematologica. 2018 Nov;103(11):e519-e521. doi: 10.3324/haematol.2018.193151. Epub 2018 May 24.

DOI:10.3324/haematol.2018.193151
PMID:29794147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6278967/
Abstract
摘要