Xu Fei, Bi Yan, Ren Decheng, Zhu Yuhao, Hu Jiaxin, Yuan Fan, Yuan Ruixue, Ma Gaini, Niu Weibo, Guo Zhenming, Sun Qianqian, Wu Xi, Cao Yanfei, Yang Fengping, He Lin, Yu Tao, Cai Lei, He Guang
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education.
Shanghai Key Laboratory of Psychotic Disorders, Brain Science and Technology Research Center.
Psychiatr Genet. 2018 Aug;28(4):73-74. doi: 10.1097/YPG.0000000000000200.
The distal long arm of chromosome 22 (22q13.3) may harbor genes implicated in schizophrenia. This is evidenced by various genetic mapping studies. BRD1 and its neighboring gene ZBED4, both located within this region, have repeatedly been found to be associated with schizophrenia in the Caucasian population. In this study, we chose seven SNPs (two BRD1 SNPs, five ZBED4 SNPs) to carry out an association study between these two genes and schizophrenia in the Chinese population. However, no significant result was obtained, which was consistent with the Japanese population. Taken together, we could conclude that BRD1 and ZBED4 might be population specific in schizophrenia and may not account for a substantial proportion of genetic risk for schizophrenia in the Asian population.
22号染色体的远端长臂（22q13.3）可能含有与精神分裂症相关的基因。各种基因定位研究证明了这一点。BRD1及其邻近基因ZBED4都位于该区域，在高加索人群中反复发现它们与精神分裂症有关。在本研究中，我们选择了7个单核苷酸多态性（2个BRD1单核苷酸多态性，5个ZBED4单核苷酸多态性）来进行这两个基因与中国人群精神分裂症之间的关联研究。然而，未获得显著结果，这与日本人群的情况一致。综上所述，我们可以得出结论，BRD1和ZBED4在精神分裂症中可能具有人群特异性，可能并不占亚洲人群精神分裂症遗传风险的很大比例。
