Public Nutrition Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.
Nutr Diabetes. 2018 May 25;8(1):31. doi: 10.1038/s41387-018-0038-9.
Several polymorphisms have been associated with obesity and type 2 diabetes in different populations.
To investigate the frequencies of a genetic polymorphism of vitamin D receptor (FokI and BsmI) in patients with T2D.
The case-control study was conducted in 138 patients with T2D and 172 control subjects, men and women (60-79 years old). The genotype and allele frequency determination of VDR polymorphisms were determined in these subjects.
The frequency of the C allele of the FokI polymorphism was significantly higher in the T2D group than in healthy subjects (p = 0.025). The frequencies of the BsmI variant were similar in subjects with and without T2D (p = 0.747). Consistent with these data, there was an association of the C allele with T2D (OR = 1.74, 95% CI = 1.003-3.084, p = 0.036), but not the AG + GG variants for BsmI (OR = 1.02, 95% CI = 0.635-1.649, p = 0.916). We can observe a significant association between carrier of the T > C variant of FokI and type 2 diabetes, adjusted for vitamin D, age, obesity (overweight and obesity), seasonality, sex and Homa-IR. Here, we show a significant association between the FokI polymorphisms (TC + CC) and T2D with an odds ratio of 1.9001 (95% CI (1.0970-3.6838), p = 0.041).
Our study suggests that the C allele (TC + CC) of the VDR-FokI gene is a possible risk factor for T2D in older people living in a community in Santiago de Chile.
在不同人群中，几种多态性与肥胖和 2 型糖尿病有关。
研究维生素 D 受体（FokI 和 BsmI）基因多态性在 2 型糖尿病患者中的频率。
本病例对照研究纳入了 138 例 2 型糖尿病患者和 172 例对照，男女（60-79 岁）。这些受试者的 VDR 多态性基因型和等位基因频率确定。
FokI 多态性 C 等位基因在 2 型糖尿病组中的频率明显高于健康对照组（p=0.025）。BsmI 变体在有和没有 2 型糖尿病的患者中的频率相似（p=0.747）。与这些数据一致，C 等位基因与 2 型糖尿病有关（OR=1.74，95%CI=1.003-3.084，p=0.036），但 BsmI 的 AG+GG 变体没有（OR=1.02，95%CI=0.635-1.649，p=0.916）。我们可以观察到 FokI 变体 T>C 的携带者与 2 型糖尿病之间存在显著关联，调整了维生素 D、年龄、肥胖（超重和肥胖）、季节性、性别和 Homa-IR。在这里，我们显示了 FokI 多态性（TC+CC）与 2 型糖尿病之间的显著关联，优势比为 1.9001（95%CI（1.0970-3.6838），p=0.041）。
我们的研究表明，VDR-FokI 基因的 C 等位基因（TC+CC）可能是圣地亚哥智利社区老年人 2 型糖尿病的一个危险因素。
