肝移植后Castleman病与移植后淋巴细胞增生性疾病：3年随访
Castleman's Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up.
作者信息
Jha Lokesh K, Ulmer Laura L, Olivera-Martinez Marco A, McCashland Timothy M, Fu Kai, Rochling Fedja A
机构信息
Division of Gastroenterology & Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Department of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
出版信息
Case Reports Hepatol. 2018 Jan 28;2018:9324872. doi: 10.1155/2018/9324872. eCollection 2018.
A 59-year-old male with a history of hepatitis C cirrhosis and history of hepatitis B exposure presented 8 months after orthotopic liver transplant (LT) with fever, fatigue, myalgia, night sweats, nonproductive cough, and shortness of breath. Bone marrow biopsy for pancytopenia was positive for Epstein-Barr virus (EBV) DNA. Lymph node biopsy for lymphadenopathy on imaging showed human herpes virus 8 (HHV8) associated Castleman's disease. Treatment included valganciclovir, rituximab, and prednisone taper with eventual discontinuation. Quantitative HHV8 DNA was initially 611,000 DNA copies/mL and was later undetectable at 6 months following treatment and remained undetectable at 3-year follow-up.
一名59岁男性，有丙型肝炎肝硬化病史且曾接触过乙肝病毒，在原位肝移植（LT）8个月后出现发热、乏力、肌痛、盗汗、干咳和气短症状。因全血细胞减少进行的骨髓活检显示爱泼斯坦-巴尔病毒（EBV）DNA呈阳性。针对影像学检查发现的淋巴结病进行的淋巴结活检显示为与人类疱疹病毒8型（HHV8）相关的卡斯特曼病。治疗包括使用缬更昔洛韦、利妥昔单抗以及逐渐减量的泼尼松，最终停药。HHV8 DNA定量最初为611,000 DNA拷贝/毫升，治疗6个月后检测不到，在3年随访时仍未检测到。
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