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颈椎前路融合术后经皮内镜下胃造口管置入的预测因素

Predictive Factors for Percutaneous Endoscopic Gastrostomy Tube Placement After Anterior Cervical Fusion.

作者信息

De la Garza-Ramos Rafael, Goodwin C Rory, Abu-Bonsrah Nancy, Jain Amit, Passias Peter G, Neuman Brian J, Sciubba Daniel M

机构信息

Johns Hopkins University, Baltimore, MD, USA.

Duke University Medical Center, Durham, NC, USA.

出版信息

Global Spine J. 2018 May;8(3):260-265. doi: 10.1177/2192568217713010. Epub 2017 Dec 18.

Abstract

STUDY DESIGN

Retrospective case-control study.

OBJECTIVES

To identify incidence and risk factors for percutaneous endoscopic gastrostomy (PEG) tube placement after anterior cervical fusion (ACF).

METHODS

Adult patients undergoing elective ACF with/without corpectomy for spondylosis from 2002 to 2011 were identified using the Nationwide Inpatient Sample database. The primary outcome measure was PEG tube placement; secondary outcomes included in-hospital mortality, total hospital charges, and discharge disposition. Multiple regression analyses were conducted to identify independent predictors of PEG tube placement.

RESULTS

Of 164 097 patients, 217 (0.13%) required a PEG tube. Patients needing PEG tube placement were older (69 vs 52 years; < .001) and more likely to be male (65% vs 46.6%; < .001) when compared with control patients. After regression analysis, age over 65 year (odds ratio [OR] = 4.16; < .001) was the strongest independent predictor for PEG tube placement; other associated factors included male gender (OR = 2.14; < .001), congestive heart failure (OR = 4.11; < .001), anemia (OR = 3.52; < .001), alcohol abuse (OR = 2.80; = .009), renal failure (OR = 2.25; = .003), chronic lung disease (OR = 1.78; < .001), corpectomy (OR = 2.16; < .001), and fusion of ≥3 segments (OR = 1.74; < .001). Mortality rate for patients requiring PEG tube placement was 5.1% versus 0.05% for controls ( < .001); average hospital charges were $134 379 versus $39 519 ( < .001), and nonroutine discharges were seen in 89.3% versus only 6.4% for controls ( < .001).

CONCLUSIONS

The incidence of PEG tube placement after ACF was 0.13% in this study. Identified risk factors included age >65, corpectomy, fusion of ≥3 segments, and various comorbidities. Additionally, there may be increased risk of in-hospital mortality, hospital charges, and nonroutine discharges among these patients.

摘要

研究设计

回顾性病例对照研究。

目的

确定颈椎前路融合术(ACF)后经皮内镜胃造口术(PEG)置管的发生率及危险因素。

方法

利用全国住院患者样本数据库识别2002年至2011年因脊柱退行性变接受选择性ACF伴或不伴椎体次全切除术的成年患者。主要观察指标是PEG置管;次要观察指标包括住院死亡率、总住院费用及出院处置情况。进行多元回归分析以确定PEG置管的独立预测因素。

结果

在164097例患者中,217例(0.13%)需要PEG置管。与对照患者相比,需要PEG置管的患者年龄更大(69岁对52岁;P<0.001),且更可能为男性(65%对46.6%;P<0.001)。回归分析后,65岁以上(比值比[OR]=4.16;P<0.001)是PEG置管最强的独立预测因素;其他相关因素包括男性(OR=2.14;P<0.001)、充血性心力衰竭(OR=4.11;P<0.001)、贫血(OR=3.52;P<0.001)、酒精滥用(OR=2.80;P=0.009)、肾衰竭(OR=2.25;P=0.003)、慢性肺病(OR=1.78;P<0.001)、椎体次全切除术(OR=2.16;P<0.001)以及融合节段≥3个(OR=1.74;P<0.001)。需要PEG置管患者的死亡率为5.1%,而对照患者为0.05%(P<0.001);平均住院费用分别为134379美元和39519美元(P<0.001),非常规出院率在需要PEG置管患者中为89.3%,而对照患者仅为6.4%(P<0.001)。

结论

本研究中ACF后PEG置管的发生率为0.13%。确定的危险因素包括年龄>65岁、椎体次全切除术、融合节段≥3个以及各种合并症。此外,这些患者住院死亡率、住院费用及非常规出院的风险可能增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/697a/5958480/b7611c602275/10.1177_2192568217713010-fig1.jpg

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