用 N-氯代-2,10-樟脑磺酰胺促进的钌催化的芳基的间 C-H 氯化反应。
Ligand-promoted ruthenium-catalyzed meta C-H chlorination of arenes using N-chloro-2,10-camphorsultam.
机构信息
CAS Key Laboratory of Receptor Research and the State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.
出版信息
Chem Commun (Camb). 2018 Jun 8;54(47):6008-6011. doi: 10.1039/c8cc03195a.
A practical meta C-H chlorination protocol is established via a Ru(0)-catalyzed ortho-metalation strategy. The use of N-chloro-2,10-camphorsultam as a new chlorinating agent is crucial for the success of the current reaction and an N-heterocyclic carbene (NHC) ligand could significantly enhance the reactivity of the catalytic transformation. The mechanistic studies reveal that an unusual ortho C-H ruthenation relay process with ortho chlorination of the C-Ru bond is probably involved.
通过 Ru(0)催化的邻位金属化策略，建立了一种实用的 Meta C-H 氯化方案。使用 N-氯-2,10-樟脑磺酰胺作为新型氯化剂对当前反应的成功至关重要，而 N-杂环卡宾（NHC）配体可以显著提高催化转化的反应性。机理研究表明，可能涉及一种不寻常的邻位 C-H 钌化接力过程，其中涉及 C-Ru 键的邻位氯化。
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