Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
Org Biomol Chem. 2018 Jun 13;16(23):4231-4235. doi: 10.1039/c8ob01015c.
A new preparation of δ-lactams is reported. In the presence of a Lewis acid promoter, alkoxyisocoumarins engage a range of N-aryl and N-alkyl imines to form δ-lactams with a pendent carboalkoxy substituent. A sulfonamide-thiourea catalyst enables the synthesis of these products in moderate to good enantioselectivities.
报道了一种新的 δ-内酰胺制备方法。在路易斯酸促进剂的存在下，烷氧基异噁唑啉与一系列 N-芳基和 N-烷基亚胺反应，形成带有支链碳烷氧基取代基的 δ-内酰胺。磺酰胺-硫脲催化剂可使这些产物以中等至良好的对映选择性合成。
