硝苯地平钙通道阻滞对肝硬化患者内脏和全身血流动力学的影响。

The effect of calcium channel blockade with nifedipine on splanchnic and systemic haemodynamics in cirrhosis.

作者信息

Macmathuna P, O'Reilly T, Kelleher D, Barry M, Feely J, Keeling P W

机构信息

Department of Clinical Medicine, Trinity College Dublin Medical School, St James' Hospital, Republic of Ireland.

出版信息

Aliment Pharmacol Ther. 1987 Dec;1(6):639-42. doi: 10.1111/j.1365-2036.1987.tb00650.x.

DOI:10.1111/j.1365-2036.1987.tb00650.x

PMID:2979692

Abstract

The splanchnic and systemic haemodynamic effects of a single sublingual dose of nifedipine (slow calcium channel blocker) in nine patients with cirrhosis of the liver and portal hypertension were studied. Nifedipine produced a significant reduction in the mean arterial blood pressure (98 +/- 5.3 vs. 86 +/- 5 mmHg, P less than 0.05) but did not alter the mean heart rate, portal venous pressure or total liver blood flow. The systemic antihypertensive effect of nifedipine can be achieved without altering liver blood-flow in patients with chronic liver disease and portal hypertension.

摘要

研究了9例肝硬化和门静脉高压患者单次舌下含服硝苯地平（慢钙通道阻滞剂）对内脏和全身血流动力学的影响。硝苯地平使平均动脉血压显著降低（98±5.3 vs. 86±5 mmHg，P<0.05），但未改变平均心率、门静脉压力或肝脏总血流量。在慢性肝病和门静脉高压患者中，硝苯地平可在不改变肝血流量的情况下实现全身降压作用。