Reith W, Haussmann A
Klinik für Diagnostische, und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, Kirrberger Straße, 66424, Homburg-Saar, Deutschland.
Radiologe. 2018 Jul;58(7):629-635. doi: 10.1007/s00117-018-0403-7.
The Dandy-Walker malformation is the most frequent cerebral malformation. It is defined by hypoplasia and upward rotation of the vermis cerebelli, a cystic enlargement of the fourth ventricle and in total an enlarged posterior fossa with cranially shifted position of the lateral sinus, tentorium and torcula herophili. This malformation was first described by Dandy and Blackfan in 1914 then supplemented again by Taggart and Walker in 1942. The current description as Dandy-Walker malformation was introduced in 1954 by Bender. In addition to these classical findings, the Dandy-Walker malformation is characterized by other abnormalities and malformations of the central nervous system (CNS) including agenesis of the corpus callosum, heterotopia, occipital meningocele, visual deficits and epilepsy. Neurogenetic and imaging examinations have led to a better understanding of this malformation.
丹迪-沃克畸形是最常见的脑畸形。它的定义为小脑蚓部发育不全并向上旋转、第四脑室囊性扩大，以及后颅窝整体扩大，伴有外侧窦、小脑幕和窦汇的颅侧移位。这种畸形最早由丹迪和布莱克范于1914年描述，随后在1942年由塔格特和沃克再次补充。目前作为丹迪-沃克畸形的描述由本德于1954年提出。除了这些经典表现外，丹迪-沃克畸形还具有中枢神经系统（CNS）的其他异常和畸形，包括胼胝体发育不全、异位、枕部脑膜膨出、视力缺陷和癫痫。神经遗传学和影像学检查使人们对这种畸形有了更好的理解。
