碱催化N-亚硝基双（2-氧代丙基）胺的分解。
Base-catalyzed decomposition of N-nitrosobis(2-oxopropyl)amine.
作者信息
Boux L J, Milligan J R, Archer M C
机构信息
Department of Medical Biophysics, University of Toronto, Ontario, Canada.
出版信息
Chem Res Toxicol. 1988 Jan-Feb;1(1):32-4. doi: 10.1021/tx00001a006.
PMID:2979708
Abstract
N-Nitrosobis(2-oxopropyl)amine, a potent carcinogen for the pancreas in Syrian hamsters, undergoes a facile, base-catalyzed, intramolecular aldol condensation to yield N-nitroso-5-hydroxy-5-methyl-3-piperidone. This cyclic nitrosamine then decomposes to yield 3-hydroxy-5-methylpyridine.
摘要
N-亚硝基双(2-氧代丙基)胺是叙利亚仓鼠胰腺的一种强效致癌物，它会发生容易的、碱催化的分子内羟醛缩合反应，生成N-亚硝基-5-羟基-5-甲基-3-哌啶酮。然后这种环状亚硝胺分解生成3-羟基-5-甲基吡啶。
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