多发性硬化症早期的认知障碍与壳聚糖酶 3 样蛋白 1 和神经丝轻链的脑脊液高浓度有关。
Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain.
机构信息
Neuroimmunology and Multiple Sclerosis Unit [Girona Biomedical Research Institute] IDIBGI, Neurology Department, Dr. Josep Trueta University Hospital, Girona, Spain.
Red Española de Esclerosis Múltiple (REEM), Madrid.
出版信息
Eur J Neurol. 2018 Sep;25(9):1189-1191. doi: 10.1111/ene.13687. Epub 2018 Jun 22.
BACKGROUND AND PURPOSE
Chitinase 3-like 1 (CHI3L1) and neurofilament light chain (NF-L) are promising biomarkers of disability in multiple sclerosis (MS). However, their role in cognitive dysfunction remains elusive. Here, we aimed to correlate cerebrospinal fluid (CSF) levels of CHI3L1 and NF-L with cognitive status in MS.
METHODS
Fifty one recently diagnosed patients were cognitively evaluated and CSF was collected. Levels of CHI3L1 and NF-L were determined by ELISA. Spearman's partial correlation coefficient was performed.
RESULTS
After adjusting cognitive scores by age, anxiety and EDSS, association was detected between CHI3L1 levels and Trail Making Test A (r = 0.348; p = 0.016) and between NF-L levels and Word List Generation (r = -0.324; p = 0.025).
CONCLUSION
High levels of CSF CHI3L1 and NF-L are associated with cognitive impairment in the early phases of MS.
背景与目的
几丁质酶 3 样蛋白 1（CHI3L1）和神经丝轻链（NF-L）是多发性硬化症（MS）残疾的有前途的生物标志物。然而，它们在认知功能障碍中的作用仍不清楚。在这里，我们旨在研究脑脊液（CSF）中 CHI3L1 和 NF-L 的水平与 MS 患者的认知状态之间的相关性。
方法
对 51 例新诊断的患者进行认知评估并采集脑脊液。通过 ELISA 法测定 CHI3L1 和 NF-L 的水平。进行 Spearman 偏相关系数分析。
结果
在通过年龄、焦虑和 EDSS 校正认知评分后，CHI3L1 水平与 Trail Making Test A（r = 0.348；p = 0.016）之间存在相关性，NF-L 水平与词语生成测试（r = -0.324；p = 0.025）之间存在相关性。
结论
CSF 中 CHI3L1 和 NF-L 水平升高与 MS 早期认知障碍有关。
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