Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Pediatr Blood Cancer. 2018 Sep;65(9):e27223. doi: 10.1002/pbc.27223. Epub 2018 May 24.
The aim of the study was to present long-term results of mandibular growth in pediatric parotid gland carcinoma survivors treated with interstitial brachytherapy.
Twenty-five survivors of pediatric parotid gland carcinoma treated with iodine-125 seed interstitial brachytherapy were included for quantitative analysis, including three dimensional (3D) cephalometry and measurement of mandibular volume.
3D cephalometry showed that the median fore-and-aft increments of the lengths of the condyle, the ramus, and the body of the mandible were 1.23, 0.19, and 1.66 mm for the affected side, respectively, and were 1.37, 1.95, and 3.42 mm for the unaffected side, respectively. The difference in increments of the ramus was statistically significant between the affected side and the unaffected side (P = 0.003; P < 0.05). Moreover, mandibular volume measurements showed that the median fore-and-aft increments of the volumes of the condyle, the ramus, and the body of the mandible were 290.62, 220.14, and 1706.40 mm for the affected side, respectively, and were 269.15, 370.40, and 1469.86 mm for the unaffected side, respectively. The difference in increments was statistically significant between the affected side and the unaffected side for the ramus (P = 0.005; P < 0.05) and the body (P = 0.043; P < .05).
Mandibular growth was affected by interstitial brachytherapy, especially for the ramus, in pediatric parotid gland carcinoma survivors treated with interstitial brachytherapy. Nevertheless, the impact was mild in these survivors.
本研究旨在展示接受碘 125 种子间质内放疗的儿童腮腺癌幸存者下颌生长的长期结果。
纳入 25 例接受碘 125 种子间质内放疗的儿童腮腺癌幸存者进行定量分析，包括三维（3D）头影测量和下颌骨体积测量。
3D 头影测量显示，受累侧髁突、下颌支和下颌体的前后增量中位数分别为 1.23、0.19 和 1.66mm，未受累侧分别为 1.37、1.95 和 3.42mm。受影响侧和未受影响侧的下颌支增量差异有统计学意义（P=0.003；P<0.05）。此外，下颌骨体积测量显示，受累侧髁突、下颌支和下颌体的前后增量中位数分别为 290.62、220.14 和 1706.40mm，未受累侧分别为 269.15、370.40 和 1469.86mm。受影响侧和未受影响侧的下颌支和下颌体增量差异有统计学意义（P=0.005；P<0.05）和（P=0.043；P<0.05）。
间质内放疗会影响下颌生长，尤其是接受间质内放疗的儿童腮腺癌幸存者的下颌支。然而，这种影响在这些幸存者中是轻微的。
