Department of Biomedical Engineering University of Wisconsin-Madison, 1300 University Avenue, Room 481, Madison, Wisconsin 53706, USA.
Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Muscle Nerve. 2018 Sep;58(3):441-448. doi: 10.1002/mus.26173. Epub 2018 Aug 23.
Neuromuscular electrical stimulation (NMES) for the treatment of swallowing disorders is delivered at a variety of stimulation frequencies. We examined the effects of stimulation frequency on tongue muscle plasticity in an aging rat model.
Eighty-six young, middle-aged, and old rats were assigned to either bilateral hypoglossal nerve stimulation at 10 or 100 Hz (5 days/week, 8 weeks), sham, or no-implantation conditions. Muscle contractile properties and myosin heavy chain (MyHC) composition were determined for hyoglossus (HG) and styloglossus (SG) muscles.
Eight weeks of 100-Hz stimulation resulted in the greatest changes in muscle contractile function with significantly longer contraction and half-decay times, the greatest reduction in fatigue, and a transition toward slowly contracting, fatigue-resistant MyHC isoforms.
NMES at 100-Hz induced considerable changes in contractile and phenotypic profiles of HG and SG muscles, suggesting higher frequency NMES may yield a greater therapeutic effect. Muscle Nerve, 2018.
神经肌肉电刺激（NMES）用于治疗吞咽障碍，其刺激频率多种多样。我们在衰老大鼠模型中研究了刺激频率对舌肌可塑性的影响。
86 只年轻、中年和老年大鼠被分配到双侧舌下神经刺激 10 或 100Hz（每周 5 天，8 周）、假刺激或无植入条件。测定颏舌肌（HG）和茎突舌骨肌（SG）的肌肉收缩特性和肌球蛋白重链（MyHC）组成。
100Hz 刺激 8 周导致肌肉收缩功能发生最大变化，表现为收缩和半衰减时间显著延长、疲劳程度显著降低、向慢收缩、抗疲劳型 MyHC 同工型转变。
100Hz 的 NMES 引起 HG 和 SG 肌肉收缩和表型特征的显著变化，提示更高频率的 NMES 可能产生更大的治疗效果。《肌肉神经》，2018 年。
