舌部成肌标志物表达随年龄的变化和基于运动的治疗的关系。
Myogenic marker expression as a function of age and exercise-based therapy in the tongue.
机构信息
Department of Biomedical Engineering, University of Wisconsin-Madison, United States of America; Department of Surgery, University of Wisconsin School of Medicine and Public Health, United States of America; Department of Stem Cell and Regenerative Biology, Harvard University, United States of America.
Department of Surgery, University of Wisconsin School of Medicine and Public Health, United States of America.
出版信息
Exp Gerontol. 2020 Dec;142:111104. doi: 10.1016/j.exger.2020.111104. Epub 2020 Oct 2.
Degeneration of tongue muscles with aging may contribute to swallowing deficits observed in elderly people. However, the capacity for tongue muscle stem cells (SCs) to regenerate and repair the aged tongue and improve tongue strength following tongue exercise (a current clinical treatment) has never been examined. We found that the expression of regenerative, myogenic markers were impaired with age and may be related to increased expression of senescent marker p16. Tongue strength increased in young adult and old rats following exercise and was related to the expression of Pax7, MyoD, myogenin, and p16. Our study also suggests that strengthening of tongue muscles via clinical rehabilitation strategies also increased the expression of SC regenerative markers in the tongue throughout the exercise duration.
随着年龄的增长，舌肌的退化可能导致老年人出现吞咽困难。然而，舌肌干细胞（SCs）的再生能力以及修复老年舌部和提高舌部力量的能力（这是目前的一种临床治疗方法）从未被研究过。我们发现，随着年龄的增长，再生和肌源性标志物的表达受损，这可能与衰老标志物 p16 的表达增加有关。在进行锻炼后，年轻成年大鼠和老年大鼠的舌部力量增加，这与 Pax7、MyoD、myogenin 和 p16 的表达有关。我们的研究还表明，通过临床康复策略增强舌部肌肉力量，也会在整个锻炼过程中增加舌部SCs 再生标志物的表达。
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