Gabriel H F, Melhem M F, Rao K N
Department of Pathology, School of Medicine, University of Pittsburgh, PA.
In Vivo. 1987 Sep-Oct;1(5):303-7.
Promotion of 7,12-dimethylbenzantracene (DMBA)-induced mammary cancer in Wistar rats, by diets containing unsaturated fat (USF) and unsaturated fat plus 4% cholestyramine (USF+ CHST) was compared to that in rats fed saturated fat (SF). The diets were fed for 100 or 200 days. Histologic examination of grossly normal mammary tissue, as well as of any tumor mass, showed a significant increase in the incidence and size of mammary tumors in USF and USF + CHST groups when compared to SF group. Moreover, in the USF + CHST group one tumor developed in one rat as early as 100 days. The serum total lipids, triglycerides and cholesterol esters decreased significantly at 200 days in USF and USF + CHST groups. These results suggest that a diet high in unsaturated fat alone, or in combination with 4% cholestyramine, promotes DMBA-induced mammary cancer in Wistar rats.
将含不饱和脂肪（USF）和含不饱和脂肪加4%消胆胺（USF + CHST）的饮食对Wistar大鼠7,12 - 二甲基苯并蒽（DMBA）诱导的乳腺癌的促进作用，与喂食饱和脂肪（SF）的大鼠进行比较。这些饮食喂养100天或200天。对大体正常乳腺组织以及任何肿瘤块进行组织学检查发现，与SF组相比，USF组和USF + CHST组乳腺肿瘤的发生率和大小显著增加。此外，在USF + CHST组中，早在100天时就有一只大鼠长出了一个肿瘤。在200天时，USF组和USF + CHST组的血清总脂质、甘油三酯和胆固醇酯显著下降。这些结果表明，单独富含不饱和脂肪的饮食，或与4%消胆胺联合的饮食，会促进Wistar大鼠DMBA诱导的乳腺癌。
