Luo J L, Zhao X M
Department of Otorhinolaryngology,Zhuhai People's Hospital,Jinan University,Zhuhai,519000,China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jul 5;30(13):1047-1048. doi: 10.13201/j.issn.1001-1781.2016.13.010.
To study the significance and application of serum eosinophil cationic protein(ECP) and IgG4 antibody in patients with allergic rhinitis treated by allergic specific immunotherapy.The level of IgG4 antibody and eosinophil cationic protein in serum was measured in 33 cases of allergic rhinitis before treatment and half a year and one year after treatment.The change of ECP level was observed in different age groups,and the relationship between serum IgG4 and ECP after treatment was analyzed.IgG4 antibody in the serum significantly increased after treatment,and the difference was statistically significant(<0.05).In the serum ECP content gradually reduced after treatment,and the difference was statistically significant(<0.05).No obvious difference in ECP level was observed among dfferent age groups after treatment (<0.05).The level of serum IgG4 was negatively correlated with serum ECP level despite statistical insignificance(=-0.138,>0.05).ECP is a sign of eosinophil activation,which is an important factor leading to the nasal inflammation.The content of serum ECP can be used as an indicator for patients with allergic rhinitis recieving nonspecific immune treatment .IgG4 antibody is a relatively reliable indicator to evaluate the treatment effect of specific immunotherapy,and may be negatively related to the serum ECP levels.
研究血清嗜酸性粒细胞阳离子蛋白（ECP）和IgG4抗体在变应性鼻炎特异性免疫治疗患者中的意义及应用。检测33例变应性鼻炎患者治疗前、治疗半年及1年后血清中IgG4抗体和嗜酸性粒细胞阳离子蛋白水平，观察不同年龄组ECP水平变化，分析治疗后血清IgG4与ECP的关系。治疗后血清中IgG4抗体明显升高，差异有统计学意义（<0.05）；血清ECP含量治疗后逐渐降低，差异有统计学意义（<0.05）；治疗后不同年龄组ECP水平差异无统计学意义（<0.05）；血清IgG4水平与血清ECP水平呈负相关，虽无统计学意义（=-0.138，>0.05）。ECP是嗜酸性粒细胞活化的标志，是导致鼻黏膜炎症的重要因素，血清ECP含量可作为变应性鼻炎患者接受非特异性免疫治疗的指标。IgG4抗体是评估特异性免疫治疗效果的相对可靠指标，且可能与血清ECP水平呈负相关。
