Wei H Q, Zhu Z W, Cao Zy, Mo J W, Xing H Y
Department of Otolaryngology, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Apr;32(7):510-513. doi: 10.13201/j.issn.1001-1781.2018.07.008.
To investigate the bacteriologic characteristics of recurrent acute rhinosinusitis(RAR).Twenty-nine patients (29 with RAR) from outpatient clinic in our hospital between June 2010 and May 2016 were enrolled in the study. Specimens of the middle meatus or olfactory cleft area using the sinus endoscopy through were transported to the laboratory for bacterial culture.Twenty-five specimens out of 29 were bacterial culture positive (culture positive rate was 86.2%).A total of 32 isolates (25 aerobic or facultative and 7 anaerobic) were recovered from the 29 cases of RAR. The predominant aerobic or facultative bacteria were Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus. The predominant anaerobic bacteria were Bacteroides fragilis and Propionibacterium. Antibiotic susceptibility tests showed that the resistance rate of these aerobic or facultative bacteria to Macrolides (Erythromycin and Azithromycin) and quinolones (Levofloxacin) was 88% and 92%, respectively. Similarly, the resistance rate of bacteria to β-lactamase antibiotics (penicillin, ampicillin, and cefazolin) was also greater than 90% (100%, 92%, and 92%, respectively). But the drug resistance of these bacteria to the thirdgeneration cephalosporin combined with beta lactamase inhibitors (Cefoperazone/sulbactam) was 20%. Among the 7 strains of anaerobic bacteria, 6 strains were sensitive to ornidazole.The major pathogens of RAR are the aerobic and facultative bacteria Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus, most of which are resistant to commonly used antibiotics.
为研究复发性急性鼻-鼻窦炎(RAR)的细菌学特征。选取2010年6月至2016年5月期间我院门诊的29例复发性急性鼻-鼻窦炎患者纳入研究。通过鼻窦内窥镜获取中鼻道或嗅裂区标本并送至实验室进行细菌培养。29份标本中有25份细菌培养呈阳性(培养阳性率为86.2%)。从29例复发性急性鼻-鼻窦炎患者中共分离出32株菌株(25株需氧菌或兼性厌氧菌和7株厌氧菌)。主要的需氧菌或兼性厌氧菌为肺炎链球菌、流感嗜血杆菌、卡他莫拉菌和金黄色葡萄球菌。主要的厌氧菌为脆弱拟杆菌和丙酸杆菌。药敏试验显示,这些需氧菌或兼性厌氧菌对大环内酯类(红霉素和阿奇霉素)和喹诺酮类(左氧氟沙星)的耐药率分别为88%和92%。同样,这些细菌对β-内酰胺酶抗生素(青霉素、氨苄西林和头孢唑林)的耐药率也大于90%(分别为100%、92%和92%)。但这些细菌对第三代头孢菌素联合β-内酰胺酶抑制剂(头孢哌酮/舒巴坦)的耐药率为20%。在7株厌氧菌中,6株对奥硝唑敏感。复发性急性鼻-鼻窦炎的主要病原体是需氧菌和兼性厌氧菌肺炎链球菌、流感嗜血杆菌、卡他莫拉菌和金黄色葡萄球菌,其中大多数对常用抗生素耐药。