Yin G F, Guo W, Chen X H, Huang Z G
Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Dec 5;31(23):1789-1792. doi: 10.13201/j.issn.1001-1781.2017.23.002.
To investigate the related factors of mucosal melanoma of head and neck with lymph node metastasis for early diagnosis and further treatments. A retrospective analysis of 117 cases of head and neck mucosal malignant melanoma patients which received surgical treatment was performed. Eleven cases of patients with pathologically confirmed lymph node metastasis and 33 cases without lymph node metastasis (1∶3) were randomly selected to analyze. The related factors of lymph node metastasis of head and neck mucosal melanoma patients including age, gender, whether the existence of recurrence, bone invasion, lesion location were analyzed. The single factor and logistic regression analysis were performed, <0.05 difference was statistically significant. The lymph node metastasis rate of head and neck mucosal melanoma was 9.40%(11/117), the single factor analysis showed that there were 3 factors to be associated with lymph node metastasis, which was recurrence (=0.0000), bone invasion (=0.001), primary position (=0.007). Recurrence (=0.021) was a risk factor for lymph node metastasis according to the Logistic regression analysis, and the impact of bone invasion (=0.487) and primary location (=0.367) remained to be further explored. The patients of head and neck mucosal melanoma with the presence of recurrent usually accompanied by a further progression of the disease, such as lymph node metastasis, so for recurrent patients should pay special attention to the situation of lymph node and choose the reasonable treatment.
为探讨头颈部黏膜黑色素瘤伴淋巴结转移的相关因素，以实现早期诊断及进一步治疗。对117例行手术治疗的头颈部黏膜恶性黑色素瘤患者进行回顾性分析。随机选取11例经病理证实有淋巴结转移的患者和33例无淋巴结转移的患者（1∶3）进行分析。对头颈部黏膜黑色素瘤患者淋巴结转移的相关因素，包括年龄、性别、是否存在复发、骨质侵犯、病变部位进行分析。进行单因素及logistic回归分析，差异<0.05具有统计学意义。头颈部黏膜黑色素瘤的淋巴结转移率为9.40%（11/117），单因素分析显示有3个因素与淋巴结转移相关，即复发（P = 0.0000）、骨质侵犯（P = 0.001）、原发部位（P = 0.007）。根据logistic回归分析，复发（P = 0.021）是淋巴结转移的危险因素，骨质侵犯（P = 0.487）和原发部位（P = 0.367）的影响仍有待进一步探讨。头颈部黏膜黑色素瘤存在复发的患者通常伴有疾病的进一步进展，如淋巴结转移，因此对于复发患者应特别关注淋巴结情况并选择合理的治疗方法。
