[创伤性脑损伤与骨折愈合相关性的研究进展]
[Research progress of correlation between traumatic brain injury and fracture healing].
作者信息
Zhang Chong, Deng Kai, Guo Yongchun, Wang Zhe, Yu Guorong
机构信息
Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan Hubei, 430071, P.R.China.
Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan Hubei, 430071,
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Jul 15;31(7):885-889. doi: 10.7507/1002-1892.201612048.
Abstract
OBJECTIVE
To review the current status and advances of the correlation between traumatic brain injury (TBI) and fracture healing.
METHODS
The related domestic and abroad literature about the correlation between TBI and fracture healing was extensively reviewed and analyzed.
RESULTS
There are a variety of studies on the correlation between TBI and fracture healing, which can be divided into two major aspects: revascularization and osteogenesis; the local and systemic changes of the neuropeptide and hormone after TBI.
CONCLUSION
TBI facilitates callus formation, the further research is needed to clarify the exact mechanism.
摘要
目的
综述创伤性脑损伤（TBI）与骨折愈合之间相关性的现状及进展。
方法
广泛查阅并分析国内外有关TBI与骨折愈合相关性的文献。
结果
关于TBI与骨折愈合相关性的研究有多种，可分为两个主要方面：血管再生与成骨；TBI后神经肽和激素的局部及全身变化。
结论
TBI促进骨痂形成，尚需进一步研究以阐明确切机制。
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本文引用的文献
1
[CHANGES OF SEMAPHORIN 3A EXPRESSION IN HEALING OF TIBIA FRACTURE AFTER TRAUMATIC BRAIN INJURY].[创伤性脑损伤后胫骨骨折愈合过程中信号素3A表达的变化]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2016 Oct 8;30(10):1225-1232. doi: 10.7507/1002-1892.20160251.
2
[Nrp-1 expression in healing process of traumatic brain injury combined with tibial fracture].[神经纤毛蛋白-1在创伤性脑损伤合并胫骨骨折愈合过程中的表达]
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Feb 28;42(2):154-160. doi: 10.11817/j.issn.1672-7347.2017.02.006.
3
Neuropeptide Y accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells.神经肽Y通过促进间充质干细胞的成骨作用加速骨折后骨愈合。
Neuropeptides. 2016 Dec;60:61-66. doi: 10.1016/j.npep.2016.09.005. Epub 2016 Oct 2.
4
Improved fracture healing in patients with concomitant traumatic brain injury: proven or not?创伤性脑损伤患者骨折愈合情况改善：已被证实还是未被证实？
Mediators Inflamm. 2015;2015:204842. doi: 10.1155/2015/204842. Epub 2015 Mar 22.
5
Clinical evidence of inflammation driving secondary brain injury: a systematic review.炎症驱动继发性脑损伤的临床证据：一项系统综述
J Trauma Acute Care Surg. 2015 Jan;78(1):184-91. doi: 10.1097/TA.0000000000000468.
6
The effects of spinal cord injury on bone healing in patients with femoral fractures.脊髓损伤对股骨骨折患者骨愈合的影响。
J Spinal Cord Med. 2014 Jul;37(4):414-9. doi: 10.1179/2045772313Y.0000000155. Epub 2013 Oct 24.
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GPNMB enhances bone regeneration by promoting angiogenesis and osteogenesis: potential role for tissue engineering bone.GPNMB 通过促进血管生成和成骨作用增强骨再生：组织工程骨的潜在作用。
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Nature. 2013 May 23;497(7450):490-3. doi: 10.1038/nature12115. Epub 2013 May 5.
9
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