Wang Hong-Shuang, Li Hui-Jing, Wang Long-Fei, Shen Zhi-Lun, Wu Yan-Chao
a School of Marine Science and Technology , Harbin Institute of Technology , Weihai , P. R. China.
b Beijing National Laboratory for Molecular Sciences (BNLMS) , Institute of Chemistry Chinese Academy of Sciences , Beijing , P. R. China.
Nat Prod Res. 2019 Jul;33(13):1891-1896. doi: 10.1080/14786419.2018.1478831. Epub 2018 May 25.
Gentisyl alcohol-type natural products, possessing various important biological properties, have been synthesized from 4-methoxyphenol by using a selective phenol monohydroxymethylation/monochlorination, a CAN oxidation and a sodium dithionite reduction as the key steps. The natural product synthesis is efficient, atom- and step-economical, and requires no protecting groups.
龙胆醇型天然产物具有多种重要的生物学特性，已通过以选择性苯酚单羟甲基化/单氯化、CAN氧化和连二亚硫酸钠还原为关键步骤，从4-甲氧基苯酚合成得到。该天然产物的合成高效、原子经济且步骤经济，并且无需保护基团。
