Department of Mathematics, Kyambogo University, P.O Box 1, Kampala, Uganda.
Department of Mathematics, Makerere University, P.O Box 7062, Kampala, Uganda.
Math Biosci. 2018 Aug;302:67-79. doi: 10.1016/j.mbs.2018.05.012. Epub 2018 May 22.
Enzyme alanine aminotransferase (ALT) elevation which reflects hepatocellular injury is a current challenge in people infected with human immunodeficiency virus (HIV) on antiretroviral therapy (ART). One of the factors that enhance the risk of hepatotoxicity is underlying diseases such as hepatitis caused by hepatitis B virus (HBV). HIV/HBV coinfected patients stand a greater risk of hepatotoxicity because all ART are toxic and liver cells (hepatocytes) that are responsible for metabolising the toxic ART, support all stages of HIV and HBV viral production. Mathematical models coupled with numerical simulations are used in this study with the aim of investigating the optimal combination of ART in HIV/HBV coinfection. Emtricitabine, tenofovir and efavirenz is the optimal combination that maximises the therapeutic effect of therapy and minimises the toxic response to medication in HIV/HBV coinfection.
酶丙氨酸氨基转移酶（ALT）升高反映了肝细胞损伤，这是接受抗逆转录病毒治疗（ART）的人类免疫缺陷病毒（HIV）感染者目前面临的挑战。增强肝毒性风险的因素之一是乙型肝炎病毒（HBV）引起的肝炎等潜在疾病。HIV/HBV 合并感染患者发生肝毒性的风险更大，因为所有的 ART 都具有毒性，而负责代谢有毒 ART 的肝细胞（肝细胞）支持 HIV 和 HBV 病毒产生的所有阶段。本研究采用数学模型结合数值模拟的方法，旨在研究 HIV/HBV 合并感染中 ART 的最佳组合。恩曲他滨、替诺福韦和依法韦仑是最佳组合，可最大限度地提高治疗效果，最大限度地减少 HIV/HBV 合并感染中对药物的毒副作用。
