Parker Antony R, Bradley Caroline, Harding Stephen, Sánchez-Ramón Silvia, Jolles Stephen, Kiani-Alikhan Sorena
The Binding Site Group Limited, Birmingham, UK.
The Binding Site Group Limited, Birmingham, UK.
J Immunol Methods. 2018 Aug;459:1-10. doi: 10.1016/j.jim.2018.05.013. Epub 2018 May 22.
Response to polysaccharide vaccination can be an invaluable tool for assessing functionality of the adaptive immune system. Measurement of antibodies raised in response to Pneumovax®23 is the current gold standard test, but there are significant challenges and constraints in both the measurement and interpretation of the response. An alternative polysaccharide vaccine approach (Salmonella typhi Vi capsule (ViCPS)) has been suggested. In the present article, we review current evidence for the measurement of ViCPS antibodies in the diagnosis of primary and secondary antibody deficiencies. In particular, we review emerging data suggesting their interpretation in combination with the response to Pneumovax®23 and comment upon the utility of these vaccines to assess humoral immune responses while receiving immunoglobulin replacement therapy (IGRT).
对多糖疫苗的反应可能是评估适应性免疫系统功能的一项宝贵工具。检测针对23价肺炎球菌多糖疫苗（Pneumovax®23）产生的抗体是目前的金标准检测方法，但在该反应的检测和解读方面均存在重大挑战和限制。有人提出了一种替代的多糖疫苗方法（伤寒Vi多糖疫苗（ViCPS））。在本文中，我们综述了目前关于检测ViCPS抗体以诊断原发性和继发性抗体缺陷的证据。特别是，我们综述了新出现的数据，这些数据表明可结合对Pneumovax®23的反应来解读ViCPS抗体，并对这些疫苗在接受免疫球蛋白替代疗法（IGRT）时评估体液免疫反应的效用进行了评论。
