Köpf-Maier P
Abteilung Anatomie der Universität Ulm, Donau, FRG.
Histol Histopathol. 1986 Oct;1(4):383-90.
The histologic phenomena occurring immediately after heterotransplantation of two human colon adenocarcinomas to athymic mice have been studied. The tumors differed with respect to velocity of growth and passage age. Three phases were discernible in both cases. (1) During the first phase, most inoculated tumor cells died. (2) The second phase was characterized by removal of the necrotic tumor cells by immigrated inflammatory cells and by penetration of the connective tissue of host animals from peripheral into central areas of the implants. The first mitoses occurred within tumor cells in close proximity to these connective tissue septa. (3) During the third phase, signs of regeneration and proliferation of tumor cells resulted in the macroscopic enlargement of xenografts. Only in this phase, the typical histologic characteristics of the tumors were formed. These observations point to the host connective tissue invading into implants to be of great importance for the stimulation of tumor cell proliferation and, therefore, for the growth of xenografts. Thus, successful heterotransplantation is obviously based on mutual events between the transplanted tumor cells and host connective tissue.
对将两个人类结肠腺癌异种移植到无胸腺小鼠后立即出现的组织学现象进行了研究。这些肿瘤在生长速度和传代年龄方面存在差异。两种情况下均可识别出三个阶段。（1）在第一阶段，大多数接种的肿瘤细胞死亡。（2）第二阶段的特征是通过迁移的炎性细胞清除坏死的肿瘤细胞，以及宿主动物的结缔组织从外周向植入物中心区域渗透。在靠近这些结缔组织间隔的肿瘤细胞内出现了最初的有丝分裂。（3）在第三阶段，肿瘤细胞的再生和增殖迹象导致异种移植物在宏观上增大。只有在这个阶段，肿瘤的典型组织学特征才形成。这些观察结果表明，宿主结缔组织侵入植入物对于刺激肿瘤细胞增殖以及异种移植物的生长非常重要。因此，成功的异种移植显然基于移植的肿瘤细胞与宿主结缔组织之间的相互作用。
