Grot Stéphanie, Leclerc Marie-Eve, Luck David
Centre de recherche, Institut universitaire en santé mentale de Montréal, Montreal, Canada; Department of Psychiatry, Faculty of Medicine, Université de Montréal, Montreal, Canada.
Centre de recherche, Institut universitaire en santé mentale de Montréal, Montreal, Canada; Department of Psychiatry, Faculty of Medicine, Université de Montréal, Montreal, Canada.
Biol Psychol. 2018 Jul;136:67-75. doi: 10.1016/j.biopsycho.2018.05.011. Epub 2018 May 23.
We designed an fMRI study to pinpoint the neural correlates of active and passive binding in working memory. Participants were instructed to memorize three words and three spatial locations. In the passive binding condition, words and spatial locations were directly presented as bound. Conversely, in the active binding condition, words and spatial locations were presented as separated, and participants were directed to intentionally create associations between them. Our results showed that participants performed better on passive binding relative to active binding. FMRI analysis revealed that both binding conditions induced greater activity within the hippocampus. Additionally, our analyses divulged regions specifically engaged in passive and active binding. Altogether, these data allow us to propose the hippocampus as a central candidate for working memory binding. When needed, a frontal-parietal network can contribute to the rearrangement of information. These findings may inform theories of working memory binding.
我们设计了一项功能磁共振成像（fMRI）研究，以确定工作记忆中主动和被动绑定的神经关联。参与者被指示记住三个单词和三个空间位置。在被动绑定条件下，单词和空间位置直接作为已绑定的形式呈现。相反，在主动绑定条件下，单词和空间位置作为分开的形式呈现，并且参与者被指示有意地在它们之间建立关联。我们的结果表明，相对于主动绑定，参与者在被动绑定上表现得更好。功能磁共振成像分析显示，两种绑定条件都会在海马体内诱发更大的活动。此外，我们的分析还揭示了专门参与被动和主动绑定的区域。总之，这些数据使我们能够提出海马体作为工作记忆绑定的核心候选者。在需要时，额顶网络可以促进信息的重新排列。这些发现可能为工作记忆绑定的理论提供参考。
