Almén T, Bååth L
Department of Diagnostic Radiology, Malmö Allmänna Sjukhus, University of Lund, Sweden.
Acta Radiol Suppl. 1987;370:61-3.
Fifteen isolated rabbit hearts were perfused with Krebs' solution according to the Langendorff technique. Before, during, and after perfusion of the heart with iopentol, iohexol and metrizoate at doses 1 ml, 2 ml and 4 ml (350 mg I/ml), ECG and left ventricular contractile force were registered. The contractile force was measured with a strain gauge sutured to the wall of the left ventricle. At each dose 12 perfusions were made. At each dose iohexol and iopentol produced a smaller decrease in contractile force than metrizoate (p less than 0.001). There was no difference in effect on contractile force between iohexol and iopentol.
根据Langendorff技术，用Krebs溶液灌注15个离体兔心。在用碘海醇、碘克沙醇和泛影酸盐以1 ml、2 ml和4 ml（350 mg I/ml）的剂量灌注心脏之前、期间和之后，记录心电图和左心室收缩力。收缩力用缝合到左心室壁上的应变片测量。每个剂量进行12次灌注。在每个剂量下，碘克沙醇和碘海醇引起的收缩力下降比泛影酸盐小（p<0.001）。碘克沙醇和碘海醇对收缩力的影响没有差异。
