Center for AIDS Research (CFAR), School of Medicine, University of California at San Diego, United States; Specialists in Global Health, Encinitas, CA, United States.
Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa.
Res Social Adm Pharm. 2019 Apr;15(4):469-473. doi: 10.1016/j.sapharm.2018.05.012. Epub 2018 May 19.
Prompt management of side effects is critical to supporting adherence to antiretroviral (ARV) medication.
This study examines the impact of presenting side effect information using simple text combined with pictograms on sustained knowledge of ARV side effects over three months.
Previously designed side effect pictograms, combined with simple text, were incorporated into a side effects panel within an ARV information leaflet. In a randomised controlled study, 116 limited literacy HIV patients taking ARVs were randomly allocated to either control (standard care) or intervention groups (standard care plus illustrated information). Side effect knowledge was assessed at baseline, and intervention patients received the illustrated leaflet. Knowledge was re-tested at one and three months. Interpretation of side effect pictograms was evaluated at one month.
In intervention patients, mean side effect knowledge increased from 45.9% (baseline) to 95.7% (three months; p<0.0001), and pictogram interpretation was good. Knowledge did not change significantly in the control group. All found the pictograms clear and useful, and endorsed their routine use.
Providing patients with simple written information containing pictograms on ARV side effects significantly improved side effect knowledge, sustained over time, in limited literacy, rural South African HIV patients.
及时处理药物副作用对于保证艾滋病病毒感染者（HIV）坚持服用抗逆转录病毒（ARV）药物至关重要。
本研究旨在探讨在三个月的时间里，通过呈现简单文字与图片相结合的副作用信息，对艾滋病病毒感染者持续了解 ARV 副作用的效果。
本研究将先前设计的副作用图片与简单文字相结合，纳入到 ARV 信息传单的副作用面板中。采用随机对照研究，将 116 名文化程度有限的 HIV 患者随机分为对照组（标准护理）和干预组（标准护理加插图信息）。在基线、一个月和三个月时评估副作用知识。在一个月时评估对副作用图片的解释。
干预组患者的副作用知识从 45.9%（基线）增加到 95.7%（三个月；p<0.0001），且对图片的解释良好。对照组患者的知识没有显著变化。所有患者都认为图片清晰易懂，并支持常规使用。
为文化程度有限的南非农村 HIV 患者提供包含 ARV 副作用图片的简单书面信息，可显著提高副作用知识，且效果可持续。
