Heindel J J
National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709.
Reprod Toxicol. 1988;2(3-4):273-9. doi: 10.1016/0890-6238(88)90031-7.
The NTP is an interagency program of the Federal Government which coordinates toxicological programs at the NIH (NIEHS), FDA (NCTR), and CDC (NIOSH) with input from NCI, NIH, OSHA, CPSC, EPA, and ATSDR. The NTP has the capability to completely characterize the toxicologic profile of a chemical, including studies of chemical disposition, genetic toxicity, immunotoxicity, teratology, reproductive toxicity, carcinogenicity, neurotoxicity, and specific organ toxicity. The NTP encourages nominations of chemicals of human health concern from all sectors of the public, including industry, labor, and the general public. The specific process of nomination, evaluation, and selection of chemicals for testing by the NTP is described. It is a multicomponent system with several evaluations and a public peer review step to assure adequate consideration of all nominated chemicals. The results of NTP studies are all peer reviewed and available to the general public as well as to the scientific community.
国家毒理学计划（NTP）是联邦政府的一个跨部门项目，它协调美国国立卫生研究院（NIEHS）、美国食品药品监督管理局（FDA，国家毒理学研究中心，NCTR）和疾病控制与预防中心（CDC，国家职业安全与健康研究所，NIOSH）的毒理学项目，并吸纳美国国家癌症研究所（NCI）、国立卫生研究院（NIH）、职业安全与健康管理局（OSHA）、消费品安全委员会（CPSC）、美国环境保护局（EPA）和美国有毒物质和疾病登记署（ATSDR）的意见。NTP有能力全面描述一种化学物质的毒理学特征，包括化学物质处置、遗传毒性、免疫毒性、致畸学、生殖毒性、致癌性、神经毒性和特定器官毒性的研究。NTP鼓励包括工业界、劳工界和公众在内的社会各界提名关注人类健康的化学物质。文中描述了NTP对化学物质进行提名、评估和选择以供测试的具体流程。它是一个多组件系统，有多项评估和一个公众同行评审步骤，以确保对所有提名的化学物质进行充分考量。NTP研究的结果都经过同行评审，可供公众和科学界使用。
