Rao M C, Gibori G
Department of Physiology and Biophysics, University of Illinois, Chicago College of Medicine 60612.
Reprod Toxicol. 1987;1(1):61-9. doi: 10.1016/0890-6238(87)90073-6.
The presence of a normally functioning corpus luteum is an essential requirement for the maintenance of gestation in mammals. The chief function of the corpus luteum in all species is to synthesize the steroid hormone progesterone that is necessary for implantation and for the subsequent development of the fetoplacental unit. Activation and maintenance of luteal function involve pituitary, placental, and ovarian hormones. Perturbation in the secretion and/or action of any of these luteotropins by exogenous compounds can profoundly affect the steroidogenic capacity of the corpus luteum. Abnormal luteal function causes failure of implantation and embryonic wastage. Both in vitro and in vivo models for assessing luteal function are available; while the former are more convenient, the model of choice for toxicological studies is one in which in vitro findings can be easily confirmed in whole animals in vivo. This article is concerned primarily with the techniques used in basic research that might be useful for the evaluation of luteal function in reproductive toxicology.
正常功能黄体的存在是维持哺乳动物妊娠的必要条件。黄体在所有物种中的主要功能是合成类固醇激素孕酮，这对胚胎着床和胎儿-胎盘单位的后续发育至关重要。黄体功能的激活和维持涉及垂体、胎盘和卵巢激素。外源性化合物对任何一种促黄体激素的分泌和/或作用的干扰都可深刻影响黄体的类固醇生成能力。黄体功能异常会导致着床失败和胚胎丢失。评估黄体功能的体外和体内模型均有；虽然前者更方便，但毒理学研究的首选模型是一种能在体内完整动物中轻松证实体外研究结果的模型。本文主要关注基础研究中可能有助于评估生殖毒理学中黄体功能的技术。
