Meat and Livestock Australia, Level 1, 40 Mount St North, Sydney 2060, Australia; Graham Centre for Agricultural Innovation, Charles Sturt University, Boorooma St, Wagga Wagga 2678, New South Wales, Australia.
Graham Centre for Agricultural Innovation, Charles Sturt University, Boorooma St, Wagga Wagga 2678, New South Wales, Australia.
Trends Parasitol. 2018 Jul;34(7):553-563. doi: 10.1016/j.pt.2018.05.001. Epub 2018 May 23.
Fifty years after anthelmintic resistance in livestock parasites was first reported, the prevalence of resistance has increased globally, and is of increasing significance in animal industries. It is now timely to reflect on what we have learnt, how research has unfolded, and what we hope to learn in the future. This Opinion paper examines ten important research events that were pivotal in resistance research. The moments include the discovery, description, and diagnosis of parasite resistance, as well as important physiological and genetic findings, and the development of online tools to help manage resistance. Despite our efforts, resistance remains the greatest challenge in parasite control. The future directions for research, including people and funding, are discussed.
抗寄生虫药物耐药性在牲畜寄生虫中首次报告 50 年后,耐药性的流行在全球范围内有所增加,在动物产业中变得越来越重要。现在是时候反思我们所学到的东西、研究是如何展开的,以及我们希望在未来学到什么。本观点文章审视了在耐药性研究中具有关键意义的十个重要研究事件。这些时刻包括寄生虫耐药性的发现、描述和诊断,以及重要的生理和遗传发现,以及开发在线工具来帮助管理耐药性。尽管我们做出了努力,但耐药性仍然是寄生虫控制的最大挑战。讨论了包括人员和资金在内的未来研究方向。