在 2018 年美国过敏、哮喘与免疫学学会会议上的 CEGIR/TIGERS 研讨会中展示了嗜酸细胞性胃肠道疾病患者的新进展。
New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology Meeting.
机构信息
Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa.
Division of Allergy, Immunology, Departments of Pediatrics and Medicine, University of California, San Diego, Rady Children's Hospital, San Diego, La Jolla, Calif.
出版信息
J Allergy Clin Immunol. 2018 Jul;142(1):48-53. doi: 10.1016/j.jaci.2018.05.005. Epub 2018 May 24.
Abstract
The Consortium of Eosinophilic Gastrointestinal Diseases and the International Gastrointestinal Eosinophil Researchers organized a day-long symposium at the recent 2018 Annual Meeting of the American Academy of Allergy, Asthma & Immunology, which was coupled for the first time with the World Allergy Organization meeting to create an international platform. The symposium featured experts in many facets of eosinophilic gastrointestinal diseases, including allergy, immunology, gastroenterology, pathology, and nutrition, and was a well-attended event. The basic science, genetics, cellular immunology, and clinical features of the diseases, with a focus on epithelial, eosinophil, and mast cell responses, as well as current and emerging treatment options, were reviewed. Here we briefly review some of the highlights of the material presented at the meeting.
摘要
嗜酸粒细胞性胃肠道疾病联合会和国际胃肠道嗜酸粒细胞研究人员在最近的 2018 年美国过敏、哮喘和免疫学学会年会上组织了为期一天的研讨会，这是该学会首次与世界过敏组织会议联合举办，为国际交流提供了一个平台。该研讨会的专家涵盖了嗜酸粒细胞性胃肠道疾病的多个领域，包括过敏、免疫学、胃肠病学、病理学和营养学，参会人数众多。会议回顾了这些疾病的基础科学、遗传学、细胞免疫学和临床特征，重点关注上皮细胞、嗜酸粒细胞和肥大细胞的反应，以及当前和新兴的治疗选择。在这里，我们简要回顾一下会议上介绍的一些重要内容。
相似文献
1
New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology Meeting.在 2018 年美国过敏、哮喘与免疫学学会会议上的 CEGIR/TIGERS 研讨会中展示了嗜酸细胞性胃肠道疾病患者的新进展。
J Allergy Clin Immunol. 2018 Jul;142(1):48-53. doi: 10.1016/j.jaci.2018.05.005. Epub 2018 May 24.
2
Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting.在2022年美国过敏、哮喘与免疫学会会议的CEGIR/TIGERs研讨会上展示的嗜酸性胃肠道疾病在理解和治疗方面的突破。
J Allergy Clin Immunol. 2023 Dec;152(6):1382-1393. doi: 10.1016/j.jaci.2023.08.021. Epub 2023 Sep 3.
3
Advances and ongoing challenges in eosinophilic gastrointestinal disorders presented at the CEGIR/TIGERs Symposium at the 2024 American Academy of Allergy, Asthma & Immunology meeting.美国过敏、哮喘与免疫学学会 2024 年会议上 CEGIR/TIGERs 研讨会呈现的嗜酸性粒细胞性胃肠道疾病的进展和持续挑战。
J Allergy Clin Immunol. 2024 Oct;154(4):882-892. doi: 10.1016/j.jaci.2024.07.022. Epub 2024 Aug 5.
4
Impressions and aspirations from the FDA GREAT VI Workshop on Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis and Perspectives for Progress in the Field.美国食品和药物管理局关于嗜酸性胃肠道疾病除嗜酸性食管炎以外的 GREAT VI 研讨会的印象和愿望，以及该领域进展的观点。
J Allergy Clin Immunol. 2022 Mar;149(3):844-853. doi: 10.1016/j.jaci.2021.12.768. Epub 2021 Dec 22.
5
Variation in prevalence, diagnostic criteria, and initial management options for eosinophilic gastrointestinal diseases in the United States.美国嗜酸粒细胞性胃肠道疾病的流行情况、诊断标准和初始治疗选择存在差异。
J Pediatr Gastroenterol Nutr. 2011 Mar;52(3):300-6. doi: 10.1097/MPG.0b013e3181eb5a9f.
6
Effect of Dupilumab on Blood Eosinophil Counts in Patients With Asthma, Chronic Rhinosinusitis With Nasal Polyps, Atopic Dermatitis, or Eosinophilic Esophagitis.度普利尤单抗对哮喘、伴鼻息肉的慢性鼻-鼻窦炎、特应性皮炎或嗜酸性食管炎患者血液嗜酸性粒细胞计数的影响。
J Allergy Clin Immunol Pract. 2022 Oct;10(10):2695-2709. doi: 10.1016/j.jaip.2022.05.019. Epub 2022 May 28.
7
Developing a standardized approach for assessing mast cells and eosinophils on tissue biopsies: A Work Group Report of the AAAAI Allergic Skin Diseases Committee.制定组织活检中评估肥大细胞和嗜酸性粒细胞的标准化方法：美国过敏、哮喘和免疫学会过敏性皮肤病委员会的一份工作组报告。
J Allergy Clin Immunol. 2021 Oct;148(4):964-983. doi: 10.1016/j.jaci.2021.06.030. Epub 2021 Aug 9.
8
Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).通过嗜酸性粒细胞性胃肠病研究人员联合会（CEGIR）推进患者护理。
J Allergy Clin Immunol. 2020 Jan;145(1):28-37. doi: 10.1016/j.jaci.2019.11.012. Epub 2019 Nov 20.
9
Building and implementing a research infrastructure for eosinophilic gastrointestinal diseases.构建并实施嗜酸性胃肠道疾病的研究基础设施。
J Allergy Clin Immunol. 2024 Jun;153(6):1536-1539. doi: 10.1016/j.jaci.2024.04.014.
10
Benralizumab Completely Depletes Gastrointestinal Tissue Eosinophils and Improves Symptoms in Eosinophilic Gastrointestinal Disease.贝那鲁肽可彻底耗尽胃肠道组织中的嗜酸性粒细胞，并改善嗜酸性粒细胞性胃肠病的症状。
J Allergy Clin Immunol Pract. 2022 Jun;10(6):1598-1605.e2. doi: 10.1016/j.jaip.2022.02.037. Epub 2022 Mar 10.
引用本文的文献
1
Esophageal Epithelium and Lamina Propria Are Unevenly Involved in Eosinophilic Esophagitis.食管上皮和固有层在嗜酸性粒细胞性食管炎中不均匀受累。
Clin Gastroenterol Hepatol. 2023 Oct;21(11):2807-2816.e3. doi: 10.1016/j.cgh.2023.03.014. Epub 2023 Mar 24.
2
Scientific journey to the first FDA-approved drug for eosinophilic esophagitis.科学之旅：首款获 FDA 批准用于嗜酸性食管炎的药物
J Allergy Clin Immunol. 2022 Dec;150(6):1325-1332. doi: 10.1016/j.jaci.2022.09.027. Epub 2022 Oct 6.
3
Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).通过嗜酸性粒细胞性胃肠病研究人员联合会（CEGIR）推进患者护理。
J Allergy Clin Immunol. 2020 Jan;145(1):28-37. doi: 10.1016/j.jaci.2019.11.012. Epub 2019 Nov 20.
4
Evaluation of gene expression change in eosinophilic gastroenteritis.嗜酸性胃肠炎中基因表达变化的评估。
Gastroenterol Hepatol Bed Bench. 2019 Summer;12(3):239-245.
5
Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis.Siglec-8 抗体可减少过敏性胃肠炎转基因小鼠模型中的嗜酸性粒细胞和肥大细胞。
JCI Insight. 2019 Oct 3;4(19):126219. doi: 10.1172/jci.insight.126219.
6
Pathophysiology of eosinophilic esophagitis: recent advances and their clinical implications.嗜酸粒细胞性食管炎的病理生理学：最新进展及其临床意义。
Expert Rev Clin Immunol. 2019 Jan;15(1):83-95. doi: 10.1080/1744666X.2019.1544893. Epub 2018 Nov 19.
本文引用的文献
1
Assessing Adherence and Barriers to Long-Term Elimination Diet Therapy in Adults with Eosinophilic Esophagitis.评估成人嗜酸性粒细胞食管炎患者长期消除饮食疗法的依从性和障碍。
Dig Dis Sci. 2018 Jul;63(7):1756-1762. doi: 10.1007/s10620-018-5045-0. Epub 2018 Apr 2.
2
Eosinophilic esophagitis and symptoms possibly related to eosinophilic esophagitis in oral immunotherapy.嗜酸性粒细胞性食管炎及口服免疫治疗中可能与嗜酸性粒细胞性食管炎相关的症状。
Ann Allergy Asthma Immunol. 2018 Mar;120(3):237-240.e4. doi: 10.1016/j.anai.2017.11.016. Epub 2018 Feb 1.
3
Creating a multi-center rare disease consortium - the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).创建一个多中心罕见病联盟——嗜酸性胃肠道疾病研究人员联盟（CEGIR）。
Transl Sci Rare Dis. 2017 Dec 18;2(3-4):141-155. doi: 10.3233/TRD-170016.
4
Elevated expression of activated T2 cells and milk-specific T2 cells in milk-induced eosinophilic esophagitis.激活的 T2 细胞和乳特异性 T2 细胞在乳诱导性嗜酸性食管炎中的高表达。
Ann Allergy Asthma Immunol. 2018 Feb;120(2):177-183.e2. doi: 10.1016/j.anai.2017.11.006. Epub 2017 Dec 28.
5
Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis.儿童嗜酸粒细胞性食管炎患者的早期环境暴露与遗传易感性变异相互作用。
J Allergy Clin Immunol. 2018 Feb;141(2):632-637.e5. doi: 10.1016/j.jaci.2017.07.010. Epub 2017 Oct 10.
6
Improvement in Esophageal Distensibility in Response to Medical and Diet Therapy in Eosinophilic Esophagitis.嗜酸性食管炎患者经药物及饮食治疗后食管扩张性的改善
Clin Transl Gastroenterol. 2017 Oct 5;8(10):e119. doi: 10.1038/ctg.2017.47.
7
Epidemiology and Natural History of Eosinophilic Esophagitis.嗜酸性食管炎的流行病学与自然史
Gastroenterology. 2018 Jan;154(2):319-332.e3. doi: 10.1053/j.gastro.2017.06.067. Epub 2017 Aug 1.
8
Lack of Knowledge and Low Readiness for Health Care Transition in Eosinophilic Esophagitis and Eosinophilic Gastroenteritis.嗜酸性食管炎和嗜酸性胃肠炎患者对医疗保健过渡的知识缺乏及准备不足。
J Pediatr Gastroenterol Nutr. 2017 Jul;65(1):53-57. doi: 10.1097/MPG.0000000000001415.
9
Influence of Age and Eosinophilic Esophagitis on Esophageal Distensibility in a Pediatric Cohort.年龄和嗜酸性食管炎对儿科队列食管扩张性的影响。
Am J Gastroenterol. 2017 Sep;112(9):1466-1473. doi: 10.1038/ajg.2017.131. Epub 2017 May 16.
10
Dietary Therapy and Nutrition Management of Eosinophilic Esophagitis: A Work Group Report of the American Academy of Allergy, Asthma, and Immunology.嗜酸性食管炎的饮食治疗与营养管理：美国过敏、哮喘与免疫学会工作组报告
J Allergy Clin Immunol Pract. 2017 Mar-Apr;5(2):312-324.e29. doi: 10.1016/j.jaip.2016.12.026.
Zotero 插件