Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany.
Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
J Affect Disord. 2018 Sep;237:112-117. doi: 10.1016/j.jad.2018.05.015. Epub 2018 May 24.
Cognitive deficits are common in patients with a depressive episode although the predictors for their development and severity remain elusive. We investigated whether subjective and objective cognitive impairment in young depressed adults would be associated with cortical thinning in medial temporal subregions.
High-resolution magnetic resonance imaging, cortical unfolding data analysis, and comprehensive assessments of subjective and objective cognitive abilities were performed on 27 young patients with a depressive episode (mean age: 29.0 ± 5.8 years) and 23 older participants without a history of a depressive disorder but amnestic mild cognitive impairment (68.5 ± 6.6 years) or normal cognition (65.2 ± 8.7 years).
Thickness reductions in parahippocampal, perirhinal and fusiform cortices were associated with subjective memory deficits only among young patients with a depressive episode and a measurable cognitive impairment.
Long-term longitudinal data would be desirable to determine the trajectories of cognitive impairment associated with depression in patients with or without cortical structure changes.
The presence of clinically significant cognitive deficits in young people with a depressive episode may identify a patient population with extrahippocampal cortical thinning.
认知缺陷在抑郁症患者中很常见，尽管其发展和严重程度的预测因素仍不清楚。我们研究了年轻抑郁症患者的主观和客观认知障碍是否与内侧颞叶亚区的皮质变薄有关。
对 27 名年轻抑郁症患者（平均年龄：29.0±5.8 岁）和 23 名无抑郁障碍但有遗忘性轻度认知障碍（68.5±6.6 岁）或正常认知（65.2±8.7 岁）的老年参与者进行了高分辨率磁共振成像、皮质展开数据分析以及主观和客观认知能力的综合评估。
在年轻的抑郁症患者中，只有那些有可测量的认知障碍且伴有主观记忆缺陷的患者，其海马旁回、旁嗅回和梭状回皮质变薄。
需要长期纵向数据来确定伴有或不伴有皮质结构变化的抑郁患者的认知障碍轨迹。
在患有抑郁症的年轻人中存在临床显著的认知缺陷，可能会识别出一个有额外海马旁皮质变薄的患者群体。
