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[成年慢性丙型肝炎患者的合并症及伴随用药情况:一项描述性流行病学分析]

[Comorbidities and concomitant medication use in adult patients with chronic hepatitis C: a descriptive epidemiological analysis].

作者信息

Wang Q, Rao H Y, Yu N, Gao S Q, Wei L

机构信息

Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing 100044, China.

Beijing Brainpower Pharma Consulting, Beijing 100021, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2018 Mar 20;26(3):225-232. doi: 10.3760/cma.j.issn.1007-3418.2018.03.011.

Abstract

To analyze the comorbidity and concomitant medications use in adult patients with chronic hepatitis C. A descriptive epidemiological methods was carried out in adult patients with chronic hepatitis C and data from 2013 to 2015 were accessed through the China Medical Insurance database. Among a chronic HCV cohort of 2 958 cases, the top five comorbidities were diabetes, hypertension, ischemic heart disease, gastroduodenitis, and co-infection with HBV and HCV. The three most common concomitant medications prescribed for mentioned comorbidities were acarbose, metformin and repaglinide (Diabetes), nifedipine, amlodipine and metoprolol (Hypertension), aspirin, nifedipine and amlodipine (Ischemic heart disease), omeprazole, pantoprazole and levolfoxacin (Gastroduodenitis), ribavirin, pegylated interferon alpha-2a and alpha-2b ( Co- infected with hepatitis B and C virus). The five most frequent comorbidities in adult patients with chronic hepatitis C are diabetes, hypertension, ischemic heart disease, gastroduodenitis, and co-infection with HBV and HCV. A concomitant medication use in those patients with comorbidities causes potential drug-drug interactions.

摘要

分析成年慢性丙型肝炎患者的合并症及伴随用药情况。对成年慢性丙型肝炎患者采用描述性流行病学方法,并通过中国医疗保险数据库获取2013年至2015年的数据。在2958例慢性丙型肝炎患者队列中,前五种合并症为糖尿病、高血压、缺血性心脏病、胃十二指肠炎症以及乙肝和丙肝合并感染。针对上述合并症开具的三种最常见伴随用药分别为阿卡波糖、二甲双胍和瑞格列奈(用于糖尿病)、硝苯地平、氨氯地平和美托洛尔(用于高血压)、阿司匹林、硝苯地平和氨氯地平(用于缺血性心脏病)、奥美拉唑、泮托拉唑和左氧氟沙星(用于胃十二指肠炎症)、利巴韦林、聚乙二醇化干扰素α-2a和α-2b(用于乙肝和丙肝合并感染)。成年慢性丙型肝炎患者中最常见的五种合并症为糖尿病、高血压、缺血性心脏病、胃十二指肠炎症以及乙肝和丙肝合并感染。这些合并症患者的伴随用药会引发潜在的药物相互作用。

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