Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.
J Korean Med Sci. 2018 May 2;33(22):e160. doi: 10.3346/jkms.2018.33.e160. eCollection 2018 May 28.
Herpes zoster (HZ) is a chronic inflammatory disease that could result in autonomic dysfunction, often leading to atrial fibrillation (AF).
From the Korean National Health Insurance Service database of 738,559 subjects, patients newly diagnosed with HZ (n = 30,685) between 2004 and 2011, with no history of HZ or AF were identified. For the non-HZ control group, 122,740 age- and sex-matched subjects were selected. AF development in the first two-years following HZ diagnosis, and during the overall follow-up period were compared among severe (requiring hospitalization, n = 2,213), mild (n = 28,472), and non-HZ (n = 122,740) groups.
There were 2,204 (1.4%) patients diagnosed with AF during follow-up, and 825 (0.5%) were diagnosed within the first two years after HZ. The severe HZ group showed higher rates of AF development (6.4 per 1,000 patient-years [PTPY]) compared to mild-HZ group (2.9 PTPY) and non-HZ group (2.7 PTPY). The risk of developing AF was higher in the first two-years after HZ diagnosis in the severe HZ group (10.6 PTPY vs. 2.7 PTPY in mild-HZ group and 2.6 PTPY in non-HZ group).
Severe HZ that requires hospitalization shows an increased risk of incident AF, and the risk is higher in the first two-years following HZ diagnosis.
带状疱疹（HZ）是一种慢性炎症性疾病，可导致自主神经功能障碍，常导致心房颤动（AF）。
从韩国国家健康保险服务数据库中，选取了 2004 年至 2011 年间新诊断为 HZ（n=30685）且无 HZ 或 AF 病史的 738559 名受试者。为了建立非 HZ 对照组，选取了 122740 名年龄和性别匹配的受试者。比较了 HZ 确诊后前两年和整个随访期间严重（需要住院治疗，n=2213）、轻度（n=28472）和非 HZ（n=122740）三组人群的 AF 发病情况。
在随访期间共诊断出 2204 名（1.4%）AF 患者，其中 825 名（0.5%）在 HZ 确诊后两年内被诊断为 AF。与轻度 HZ 组（2.9 PTPY）和非 HZ 组（2.7 PTPY）相比，严重 HZ 组的 AF 发生率更高（6.4 人/1000 患者年[PTPY]）。严重 HZ 组在 HZ 确诊后的前两年内发生 AF 的风险更高（10.6 PTPY 比轻度 HZ 组的 2.7 PTPY 和非 HZ 组的 2.6 PTPY）。
需要住院治疗的严重 HZ 发生 AF 的风险增加，且在 HZ 确诊后的前两年内风险更高。
