儿童淋巴细胞白血病放疗后发生的胶质瘤。

Gliomas in children following radiation therapy for lymphoblastic leukemia.

作者信息

Edwards M K, Terry J G, Montebello J F, Hornback N B, Kuharik M A

机构信息

Department of Radiology, Indiana University Medical Center, Indianapolis.

出版信息

Acta Radiol Suppl. 1986;369:651-3.

PMID:2980585

Abstract

Four children treated for acute lymphoblastic leukemia developed intracranial gliomas between 40 and 120 months following multiagent chemotherapy, prophylactic whole brain irradiation, and intrathecal Methotrexate. The diagnosis of glioma was confirmed in each case with biopsy or autopsy. These children were part of a larger series of 73 patients with acute lymphoblastic leukemia treated at Indiana University receiving 24 Gy as per the protocol guidelines of the Children's Cancer Study Group. Currently 42 patients of the original 73 children survive in continuous remission.

摘要

4名接受急性淋巴细胞白血病治疗的儿童在接受多药化疗、预防性全脑照射和鞘内注射甲氨蝶呤后40至120个月内发生了颅内胶质瘤。每例胶质瘤的诊断均经活检或尸检证实。这些儿童是印第安纳大学接受治疗的73例急性淋巴细胞白血病患者中的一部分，按照儿童癌症研究组的方案指南接受了24 Gy的照射。最初的73名儿童中目前有42名患者持续缓解存活。