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活体供体工资损失试验:研究原理与方案

The Living Donor Lost Wages Trial: Study Rationale and Protocol.

作者信息

Rodrigue James R, Fleishman Aaron, Carroll Michaela, Evenson Amy R, Pavlakis Martha, Mandelbrot Didier A, Baliga Prabhakar, Howard David H, Schold Jesse D

机构信息

The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA.

Harvard Medical School, Boston, MA.

出版信息

Curr Transplant Rep. 2018 Mar;5(1):45-54. Epub 2018 Jan 19.

Abstract

PURPOSE OF REVIEW

This paper describes the background, rationale, and design of an NIH-funded, single-center study to test the impact of offering reimbursement for donor lost wages incurred during the post-nephrectomy recovery period on the live donor kidney transplant (LDKT) rate in newly evaluated kidney transplant candidates, to examine whether offering reimbursement for donor lost wages reduces racial disparity in LDKT rates, and to determine whether higher reimbursement amounts lead to higher LDKT rates.

RECENT FINDINGS

LDKT is the optimal treatment for renal failure. However, living kidney donation has declined in the past decade, particularly among men, younger adults, blacks, and low-income adults. There is evidence that donation-related costs may deter both transplant candidates and potential donors from considering LDKT. Lost wages is a major source of financial loss for some living donors and, unlike travel and lodging expenses, is not reimbursed by financial assistance programs.

SUMMARY

The study addresses the transplant community's call to reduce the financial burden of living donation and examine its impact on LDKT rates. Findings have the potential to influence policy, clinical practice, LDKT access, and income-related and racial disparities in LDKT and living donation.

摘要

综述目的

本文描述了一项由美国国立卫生研究院资助的单中心研究的背景、基本原理和设计,该研究旨在测试对肾切除术后恢复期捐赠者的误工损失提供补偿,对新评估的肾移植候选人的活体供肾移植(LDKT)率的影响,研究为捐赠者的误工损失提供补偿是否能减少LDKT率中的种族差异,并确定更高的补偿金额是否会导致更高的LDKT率。

最新发现

LDKT是肾衰竭的最佳治疗方法。然而,活体肾捐赠在过去十年中有所下降,尤其是在男性、年轻人、黑人及低收入成年人中。有证据表明,与捐赠相关的费用可能会阻碍移植候选人和潜在捐赠者考虑进行LDKT。误工损失是一些活体捐赠者经济损失的主要来源,而且与差旅和住宿费用不同,误工损失得不到经济援助项目的补偿。

总结

该研究回应了移植界减轻活体捐赠经济负担并研究其对LDKT率影响的呼吁。研究结果有可能影响政策、临床实践、LDKT的可及性,以及LDKT和活体捐赠中与收入相关的差异及种族差异。

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本文引用的文献

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Am J Transplant. 2017 Jan;17 Suppl 1(Suppl 1):21-116. doi: 10.1111/ajt.14124.
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Am J Transplant. 2017 Feb;17(2):578-580. doi: 10.1111/ajt.14036. Epub 2016 Oct 3.
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Financial Neutrality for Living Organ Donors: Reasoning, Rationale, Definitions, and Implementation Strategies.
Am J Transplant. 2016 Jul;16(7):1973-81. doi: 10.1111/ajt.13813. Epub 2016 May 9.
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Direct and Indirect Costs Following Living Kidney Donation: Findings From the KDOC Study.
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Living-Donor Kidney Transplantation: Reducing Financial Barriers to Live Kidney Donation--Recommendations from a Consensus Conference.
Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1696-702. doi: 10.2215/CJN.01000115. Epub 2015 May 22.
9
Predonation Direct and Indirect Costs Incurred by Adults Who Donated a Kidney: Findings From the KDOC Study.
Am J Transplant. 2015 Sep;15(9):2387-93. doi: 10.1111/ajt.13286. Epub 2015 May 5.

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