Acylphloroglucinols as kinase inhibitors from .

Three new acylphloroglucinols (-) and four known biosynthetically related analogs (-) were isolated from the ethanol extract of a brown alga . Structures for - were characterized detailed spectroscopic analyses especially 2D NMR data. Screening of these compounds in Alzheimer's diseases-related bioassays revealed moderate inhibitory activities against two therapeutically important kinases, CDK5 and GSK3β. A preliminary structure-activity relationship was also discussed.