Peña Camila, Ortiz Manuela, Voisin Javier, Peralta Alexis, Balboa Viviana, Delgado Florencia
Sección de Hematología, Hospital del Salvador, Santiago, Chile.
Laboratorio Reumatología/Inmunología, Hospital del Salvador, Santiago, Chile.
Rev Med Chil. 2018 Jan;146(1):64-67. doi: 10.4067/s0034-98872018000100064.
International guidelines suggest a screening panel for monoclonal gammopathies that contains serum protein electrophoresis (SPE), free light chain (FLC) measurements and immunofixation. This combination provides the possibility of a timely accurate diagnosis.
To evaluate the sensibility of a simple screening panel (SPE + FLC).
We analyzed 191 consecutive serum samples of patients with a suspected monoclonal gammopathy (MG).
Seventy five patients were diagnosed with MG. The sensitivity and specificity of the combination of SPE + FLC for the diagnosis of monoclonal gammopathy were 95% (95% confidence intervals 89-99) and 99% (95% confidence intervals 96-100), respectively.
We were able to validate the international recommendations on the diagnostic accuracy of this simple combination of two tests in serum for monoclonal gammopathy.
国际指南建议采用一个包含血清蛋白电泳（SPE）、游离轻链（FLC）检测和免疫固定的单克隆丙种球蛋白病筛查组合。这种组合提供了及时准确诊断的可能性。
评估一个简单筛查组合（SPE + FLC）的敏感性。
我们分析了191例疑似单克隆丙种球蛋白病（MG）患者的连续血清样本。
75例患者被诊断为MG。SPE + FLC组合诊断单克隆丙种球蛋白病的敏感性和特异性分别为95%（95%置信区间89 - 99）和99%（95%置信区间96 - 100）。
我们能够验证关于血清中这两项检测的简单组合对单克隆丙种球蛋白病诊断准确性的国际建议。
