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No proof of a causal relationship between antiepileptic drug treatment and incidence of dementia. Comment on: Use of antiepileptic drugs and dementia risk-An analysis of Finnish health register and German health insurance data.

作者信息

Helmstaedter Christoph, Beghi Ettore, Elger Christian E, Kälviäinen Reetta, Malmgren Kristina, May Theodor W, Perucca Emilio, Trinka Eugen, Witt Juri-Alexander

机构信息

Department of Epileptology, University of Bonn Medical Center, Bonn, Germany.

Department of Neuroscience, IRCCS Istituto Mario Negri, Milan, Italy.

出版信息

Epilepsia. 2018 Jul;59(7):1303-1306. doi: 10.1111/epi.14432. Epub 2018 May 28.

DOI:10.1111/epi.14432
PMID:29806877
Abstract
摘要

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1
No proof of a causal relationship between antiepileptic drug treatment and incidence of dementia. Comment on: Use of antiepileptic drugs and dementia risk-An analysis of Finnish health register and German health insurance data.没有证据表明抗癫痫药物治疗与痴呆症发病率之间存在因果关系。评论：抗癫痫药物的使用与痴呆风险——芬兰健康登记和德国健康保险数据分析。
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2
Reply to: Use of Antiepileptic Drugs and Dementia Risk-an Analysis of Finnish Health Register and German Health Insurance Data.回复：抗癫痫药物的使用与痴呆风险——芬兰健康登记数据和德国健康保险数据分析
J Am Geriatr Soc. 2018 Sep;66(9):1853-1854. doi: 10.1111/jgs.15512. Epub 2018 Aug 9.
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Comment on: Use of Antiepileptic Drugs and Dementia Risk.关于《抗癫痫药物的使用与痴呆风险》的评论
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Use of Antiepileptic Drugs and Dementia Risk-an Analysis of Finnish Health Register and German Health Insurance Data.抗癫痫药物的使用与痴呆风险——基于芬兰健康登记和德国健康保险数据的分析。
J Am Geriatr Soc. 2018 Jul;66(6):1123-1129. doi: 10.1111/jgs.15358. Epub 2018 Mar 22.
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No Evidence of a Causal Role of Antiepileptic Drug Treatment with Regard to the Development of Dementia.没有证据表明抗癫痫药物治疗与痴呆症的发生存在因果关系。
J Am Geriatr Soc. 2018 Sep;66(9):1850-1852. doi: 10.1111/jgs.15467. Epub 2018 Aug 9.
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Antiepileptic drugs with histone deacetylase inhibition activity and prostate cancer risk: a population-based case-control study.具有组蛋白去乙酰化酶抑制活性的抗癫痫药物与前列腺癌风险：一项基于人群的病例对照研究。
Cancer Causes Control. 2016 May;27(5):637-45. doi: 10.1007/s10552-016-0737-2. Epub 2016 Apr 1.
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Antiepileptic drug use and birth rate in patients with epilepsy--a population-based cohort study in Finland.癫痫患者抗癫痫药物的使用与出生率——芬兰一项基于人群的队列研究
Hum Reprod. 2006 Sep;21(9):2290-5. doi: 10.1093/humrep/del194. Epub 2006 Jun 3.
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Use of antiepileptic drugs among community-dwelling persons with Alzheimer's disease in Finland.在芬兰，社区居住的阿尔茨海默病患者中抗癫痫药物的使用情况。
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Temporal changes in the incidence of epilepsy in Finland: nationwide study.芬兰癫痫发病率的时间变化：全国性研究。
Epilepsy Res. 2006 Oct;71(2-3):206-15. doi: 10.1016/j.eplepsyres.2006.06.017. Epub 2006 Jul 31.
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Cancer incidence among patients using antiepileptic drugs: a long-term follow-up of 28,000 patients.使用抗癫痫药物患者的癌症发病率：对28000名患者的长期随访
Eur J Clin Pharmacol. 2002 May;58(2):137-41. doi: 10.1007/s00228-002-0429-6. Epub 2002 Mar 21.

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Do Epilepsy Patients with Cognitive Impairment Have Alzheimer's Disease-like Brain Metabolism?患有认知障碍的癫痫患者是否具有类似阿尔茨海默病的脑代谢？
Biomedicines. 2023 Apr 6;11(4):1108. doi: 10.3390/biomedicines11041108.
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Development of a machine learning model to predict mild cognitive impairment using natural language processing in the absence of screening.利用自然语言处理技术在不进行筛查的情况下开发一种预测轻度认知障碍的机器学习模型。
BMC Med Inform Decis Mak. 2022 May 12;22(1):129. doi: 10.1186/s12911-022-01864-z.
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Epilepsy and Alzheimer's Disease: Current Concepts and Treatment Perspective on Two Closely Related Pathologies.
癫痫与阿尔茨海默病：两种密切相关疾病的当前概念与治疗观点。
Curr Neuropharmacol. 2022;20(11):2029-2033. doi: 10.2174/1570159X20666220507020635.
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Aiding the discovery of new treatments for dementia by uncovering unknown benefits of existing medications.通过揭示现有药物的未知益处，助力发现痴呆症的新疗法。
Alzheimers Dement (N Y). 2019 Dec 9;5:862-870. doi: 10.1016/j.trci.2019.07.012. eCollection 2019.