The Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, 15782 Santiago de Compostela, A Coruña, Spain; Hospital Clinical Biochemistry Laboratory of the University of Santiago de Compostela, 15706 Santiago de Compostela, A Coruña, Spain.
The Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, 15782 Santiago de Compostela, A Coruña, Spain; Hospital Clinical Biochemistry Laboratory of the University of Santiago de Compostela, 15706 Santiago de Compostela, A Coruña, Spain.
Diabetes Res Clin Pract. 2018 Aug;142:100-109. doi: 10.1016/j.diabres.2018.05.026. Epub 2018 May 26.
To investigate whether continuous glucose monitoring (CGM) reveals patterns of glycaemic behaviour, the detection of which might improve early diagnosis of dysglycaemia.
A total 1521 complete days of valid CGM data were recorded under real-life conditions from a healthy sample of a Spanish community, as were matching FPG and HbA1 data. No participant was pregnant, had a history of kidney or liver disease, or was taking drugs known to affect glycaemia.
CGM and fingerstick measurements showed a mean relative absolute difference of 6.9 ± 2.2%. All subjects were normoglycaemic according to FPG and HbA except 21% who were prediabetic. The normoglycaemic subjects had a 24-hour mean blood glucose concentration (MBG) of 5.7 ± 0.4 mmol/L, spending a median of 97% of their time within the target range (3.9-7.8 mmol/L). 73% of them experienced episodes with blood glucose levels above the threshold for impaired glucose tolerance, and 5% levels above the threshold for diabetes. These normoglycaemic participants with episodes of high glycaemia had glycaemic variabilities similar to those of prediabetic subjects with episodes of similar intensity or combined duration.
CGM is a better indicator of possible early dysglycaemia than either FPG or HbA1c.
研究连续血糖监测（CGM）是否能揭示血糖行为模式，这些模式的检测可能有助于早期诊断糖代谢异常。
在真实环境下，对来自西班牙社区的健康人群进行了为期 1521 天的 CGM 数据采集，同时记录了匹配的 FPG 和 HbA1 数据。所有参与者均无肾脏或肝脏疾病史，也未服用已知会影响血糖的药物，且无妊娠史。
CGM 和指尖测量的平均相对绝对差值为 6.9±2.2%。根据 FPG 和 HbA1c，所有受试者均为血糖正常，但有 21%的受试者处于糖尿病前期。血糖正常的受试者 24 小时平均血糖浓度（MBG）为 5.7±0.4mmol/L，中位数 97%的时间处于目标范围（3.9-7.8mmol/L）内。其中 73%的受试者出现了血糖水平高于糖耐量受损阈值的情况，5%的受试者出现了血糖水平高于糖尿病阈值的情况。这些血糖正常但有高血糖发作的受试者的血糖变异性与有类似强度或持续时间的高血糖发作的糖尿病前期受试者相似。
与 FPG 或 HbA1c 相比，CGM 是早期糖代谢异常的更好指标。
