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甲状腺和甲状旁腺手术后阿片类药物的处方和使用模式。

Prescription and Usage Pattern of Opioids after Thyroid and Parathyroid Surgery.

机构信息

1 School of Medicine, Georgetown University, Washington, DC, USA.

2 Department of Otolaryngology-Head and Neck Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.

出版信息

Otolaryngol Head Neck Surg. 2019 Mar;160(3):388-393. doi: 10.1177/0194599818779776. Epub 2018 May 29.

DOI:10.1177/0194599818779776
PMID:29807482
Abstract

OBJECTIVE

We seek to characterize the prescribing patterns of opioids, opioid consumption, and pain severity after thyroid and parathyroid surgery. We also aim to determine if a relationship exists between preoperative medication use and postoperative pain or opioid consumption.

STUDY DESIGN

Case series with chart review.

SETTING

Academic university hospital.

SUBJECTS AND METHODS

Medical records of 237 adult patients undergoing thyroid and parathyroid surgery were included. Clinicopathologic data were collected, including pain scores, preoperative medications, and inpatient pain medications.

RESULTS

The mean maximum pain score was 5.74 and varied by surgery type (range, 0-10). Mean pain score decreased to 2.61 upon discharge (0-8) and to 0.51 at the first postoperative visit. Patients with a length of stay exceeding 1 day had significantly higher maximum pain scores than those with a length of stay of 0 or 1 day (8 vs 5.58, P < .001). Morphine milligram equivalents while in the hospital averaged 25.4 per day and were significantly influenced by preoperative opioid use (0-202). Acetaminophen/oxycodone was the most commonly prescribed opioid. The mean number of pills prescribed postoperatively was 43.1 (0-120).

CONCLUSION

In our population, patients are discharged with opioid prescriptions that may be in excess of their requirements following thyroid and parathyroid surgery. Preoperative opioid use was associated with higher postoperative pain score and, on multivariate analysis, greater inpatient opioid consumption. Further investigation is warranted to ensure that we are prescribing opioids appropriately following thyroid and parathyroid surgery.

摘要

目的

我们旨在描述甲状腺和甲状旁腺手术后阿片类药物的开具模式、使用情况和疼痛严重程度。我们还旨在确定术前用药与术后疼痛或阿片类药物使用之间是否存在关系。

研究设计

病例系列,病历回顾。

设置

学术大学医院。

受试者和方法

纳入了 237 名接受甲状腺和甲状旁腺手术的成年患者的病历。收集了临床病理数据,包括疼痛评分、术前用药和住院期间的止痛药物。

结果

平均最大疼痛评分为 5.74,手术类型不同(范围 0-10)。出院时平均疼痛评分降至 2.61(0-8),第一次术后就诊时降至 0.51。住院时间超过 1 天的患者的最大疼痛评分明显高于住院时间为 0 天或 1 天的患者(8 比 5.58,P <.001)。住院期间平均每天的吗啡毫克当量为 25.4,且受术前阿片类药物使用的显著影响(0-202)。扑热息痛/羟考酮是最常开的阿片类药物。术后开的止痛药平均数量为 43.1(0-120)。

结论

在我们的人群中,患者出院时开具的阿片类药物处方可能超过甲状腺和甲状旁腺手术后的需求。术前阿片类药物的使用与术后疼痛评分较高有关,并且在多变量分析中,与住院期间阿片类药物消耗增加有关。有必要进一步调查,以确保我们在甲状腺和甲状旁腺手术后适当开具阿片类药物。

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